Reactome | Autophosphorylation and activation of CAMK2

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Autophosphorylation and activation of CAMK2 Show undefined attributes

authored	[InstanceEdit:4332362] Rothfels, K, 2013-08-16
catalystActivity	[CatalystActivity:4332344] protein serine/threonine kinase activity of CAMK2:CaM [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4332362] Rothfels, K, 2013-08-16
dbId	4332363
displayName	Autophosphorylation and activation of CAMK2
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-4332358] Dissociation of CaM and CAMK2 autophosphorylation - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-4332345] CAMK2:CaM [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4332320] Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Autophosphorylation and activation of CAMK2
orthologousEvent	[Reaction:R-CEL-4332363] Autophosphorylation and activation of CAMK2 - Caenorhabditis elegans [Reaction:R-DME-4332363] Autophosphorylation and activation of CAMK2 - Drosophila melanogaster [Reaction:R-CFA-4332363] Autophosphorylation and activation of CAMK2 - Canis familiaris [Reaction:R-RNO-4332363] Autophosphorylation and activation of CAMK2 - Rattus norvegicus [Reaction:R-MMU-4332363] Autophosphorylation and activation of CAMK2 - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-4332348] p-T286 CAMK2:CaM [cytosol]
precedingEvent	[Reaction:R-HSA-4332359] Active calmodulin binds CAMK2 - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4332363
summation	[Summation:4332351] Binding of CaM to CAMK2 displaces the autoinhibitory loop fr...

Referrals

(hasEvent)	[Pathway:R-HSA-4086398] Ca2+ pathway
(precedingEvent)	[Reaction:R-HSA-4332358] Dissociation of CaM and CAMK2 autophosphorylation

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