Reactome | Ca2+ pathway

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Ca2+ pathway Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224479
displayName	Ca2+ pathway
eventOf	[Pathway:R-RNO-3858494] Beta-catenin independent WNT signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20146] Wnt signaling pathway, calcium modulating pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-2730872] Activation of Calcineurin - Rattus norvegicus [Reaction:R-RNO-4551451] Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling - Rattus norvegicus [BlackBoxEvent:R-RNO-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Rattus norvegicus [Reaction:R-RNO-4086392] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-RNO-4332359] Active calmodulin binds CAMK2 - Rattus norvegicus [Reaction:R-RNO-4332363] Autophosphorylation and activation of CAMK2 - Rattus norvegicus [Reaction:R-RNO-4332358] Dissociation of CaM and CAMK2 autophosphorylation - Rattus norvegicus [Reaction:R-RNO-4332356] CAMK2 binds MAP3K7 - Rattus norvegicus [Reaction:R-RNO-4411402] Activation of NLK - Rattus norvegicus [BlackBoxEvent:R-RNO-4411373] NLK translocates to nucleus - Rattus norvegicus [Reaction:R-RNO-4411383] NLK phosphorylates TCF/LEF - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ca2+ pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4086398
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3858494] Beta-catenin independent WNT signaling
(inferredTo)	[Pathway:R-HSA-4086398] Ca2+ pathway

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