Reactome | G beta:gamma signalling through PI3Kgamma

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G beta:gamma signalling through PI3Kgamma Show undefined attributes

authored	[InstanceEdit:392446] Jupe, S, 2009-03-04 10:18:49
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392450] Jupe, S, 2009-03-04 10:33:47
crossReference	[DatabaseIdentifier:12325688] BioModels Database:BIOMD0000000137 [DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12325396] BioModels Database:BIOMD0000000088
dbId	392451
displayName	G beta:gamma signalling through PI3Kgamma
edited	[InstanceEdit:435389] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-397795] G-protein beta:gamma signalling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-392295] Gbeta:gamma recruits PI3K gamma - Homo sapiens [Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens [Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:425620] PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis [LiteratureReference:425628] Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	G beta:gamma signalling through PI3Kgamma
orthologousEvent	[Pathway:R-SCE-392451] G beta:gamma signalling through PI3Kgamma - Saccharomyces cerevisiae [Pathway:R-SPO-392451] G beta:gamma signalling through PI3Kgamma - Schizosaccharomyces pombe [Pathway:R-DDI-392451] G beta:gamma signalling through PI3Kgamma - Dictyostelium discoideum [Pathway:R-CEL-392451] G beta:gamma signalling through PI3Kgamma - Caenorhabditis elegans [Pathway:R-DME-392451] G beta:gamma signalling through PI3Kgamma - Drosophila melanogaster [Pathway:R-GGA-392451] G beta:gamma signalling through PI3Kgamma - Gallus gallus [Pathway:R-XTR-392451] G beta:gamma signalling through PI3Kgamma - Xenopus tropicalis [Pathway:R-DRE-392451] G beta:gamma signalling through PI3Kgamma - Danio rerio [Pathway:R-SSC-392451] G beta:gamma signalling through PI3Kgamma - Sus scrofa [Pathway:R-BTA-392451] G beta:gamma signalling through PI3Kgamma - Bos taurus [Pathway:R-CFA-392451] G beta:gamma signalling through PI3Kgamma - Canis familiaris [Pathway:R-RNO-392451] G beta:gamma signalling through PI3Kgamma - Rattus norvegicus [Pathway:R-MMU-392451] G beta:gamma signalling through PI3Kgamma - Mus musculus
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-392451
summation	[Summation:425646] PI3K gamma (PI3KG) is a heterodimer consisting of a p110 cat...

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(hasEvent)

[Pathway:R-HSA-397795] G-protein beta:gamma signalling

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