G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Stable Identifier
R-HSA-392300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Biochemical and cellular studies have shown that the p101/p110 form of PI3K gamma is substantially activated by G beta:gamma in a manner that is dependent on p101.

Literature References
PubMed ID Title Journal Year
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Stoyanov, B, Volinia, S, Hanck, T, Rubio, I, Loubtchenkov, M, Malek, D, Stoyanova, S, Vanhaesebroeck, B, Dhand, R, Nurnberg, B

Science 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created