G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Stable Identifier
R-HSA-392300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
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Biochemical and cellular studies have shown that the p101/p110 form of PI3K gamma is substantially activated by G beta:gamma in a manner that is dependent on p101.

Literature References
PubMed ID Title Journal Year
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Stoyanov, B, Volinia, S, Hanck, T, Rubio, I, Loubtchenkov, M, Malek, D, Stoyanova, S, Vanhaesebroeck, B, Dhand, R, Nurnberg, B

Science 1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]
Physical Entity
G-protein beta-gamma:PI3K gamma [plasma membrane]
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (0046934)
Orthologous Events
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
Authored
Jupe, S  (2009-03-02)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-03-02)