G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Stable Identifier
R-HSA-392300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
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Biochemical and cellular studies have shown that the p101/p110 form of PI3K gamma is substantially activated by G beta:gamma in a manner that is dependent on p101.
Literature References
PubMed ID Title Journal Year
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Malek, D, Nurnberg, B, Dhand, R, Vanhaesebroeck, B, Volinia, S, Loubtchenkov, M, Stoyanov, B, Hanck, T, Stoyanova, S, Rubio, I

Science 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]

Physical Entity
G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jupe, S  (2009-03-02)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-03-02)
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