Reactome | Translocation of Vav1 to CD28

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Translocation of Vav1 to CD28 Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389353] Garapati, P V, 2009-01-06 13:42:50
dbId	389352
displayName	Translocation of Vav1 to CD28
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-389354] Activation of Vav1 - Homo sapiens
input	[Complex:R-HSA-388786] CD28:Grb2 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389267] Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription [LiteratureReference:389268] Vav-family proteins in T-cell signalling [LiteratureReference:389283] CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Translocation of Vav1 to CD28
orthologousEvent	[Reaction:R-MMU-389352] Translocation of Vav1 to CD28 - Mus musculus [Reaction:R-GGA-389352] Translocation of Vav1 to CD28 - Gallus gallus [Reaction:R-XTR-389352] Translocation of Vav1 to CD28 - Xenopus tropicalis [Reaction:R-SSC-389352] Translocation of Vav1 to CD28 - Sus scrofa [Reaction:R-BTA-389352] Translocation of Vav1 to CD28 - Bos taurus [Reaction:R-CFA-389352] Translocation of Vav1 to CD28 - Canis familiaris [Reaction:R-RNO-389352] Translocation of Vav1 to CD28 - Rattus norvegicus
output	[Complex:R-HSA-389334] VAV1:PIP3:CD28:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-388814] Grb2 binds CD28 - Homo sapiens [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389352
summation	[Summation:389284] Vav1 protein is a cytoplasmic guanine nucleotide exchange fa...
updateTrackers	[UpdateTracker:9928519] Update Tracker - [Reaction:389352] Translocation of Vav1 to CD28 - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928519] Update Tracker - [Reaction:389352] Translocation of Vav1 to CD28 - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway
(precedingEvent)	[Reaction:R-HSA-389354] Activation of Vav1