CD28 bound PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-389158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Upon binding to CD28, the PI3K enzyme catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This conversion of PIP2 to PIP3 is significant as PIP3 acts as a docking site on the plasma membrane for several downstream signaling molecules, including 3-phosphoinositide-dependent kinase-1 (PDK1) and protein kinase B (PKB or Akt), which are essential for T cell proliferation, survival, and activation (Pages et al. 1994, Appleman et al. 2002).
Literature References
PubMed ID Title Journal Year
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Participates
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD28:PI3K [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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