CD28 bound PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-389158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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CD28 bound PI3K phosphorylates PIP2 to PIP3
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PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.

Literature References
PubMed ID Title Journal Year
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD28:PI3K [plasma membrane]
Physical Entity
CD28:PI3K [plasma membrane]
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (0046934)
Orthologous Events
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-22)
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