Reactome | Upon binding to CD28, the PI3K enzyme catalyzes the phosphor...

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created	[InstanceEdit:389374] Garapati, P V, 2009-01-06 15:47:20
dbId	389373
displayName	Upon binding to CD28, the PI3K enzyme catalyzes the phosphor...
literatureReference	[LiteratureReference:9927281] Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling [LiteratureReference:9927292] CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells
modified	[InstanceEdit:9927288] Tiwari, Krishna, 2024-11-05
schemaClass	Summation
text	Upon binding to CD28, the PI3K enzyme catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This conversion of PIP2 to PIP3 is significant as PIP3 acts as a docking site on the plasma membrane for several downstream signaling molecules, including 3-phosphoinositide-dependent kinase-1 (PDK1) and protein kinase B (PKB or Akt), which are essential for T cell proliferation, survival, and activation (Pages et al. 1994, Appleman et al. 2002).

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