Reactome | Expression of CEBPA

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Expression of CEBPA Show undefined attributes

authored	[InstanceEdit:556811] May, B, 2010-03-23
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:560489] May, B, 2010-03-24
dbId	560491
displayName	Expression of CEBPA
edited	[InstanceEdit:556811] May, B, 2010-03-23
eventOf	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1183032] Expression of GLUT4 - Homo sapiens [BlackBoxEvent:R-HSA-1183003] Expression of Leptin - Homo sapiens [BlackBoxEvent:R-HSA-1183058] Expression of Adiponectin - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-442497] Expression of Cebpa - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5640210] CEBPA gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:560478] Identification of novel PPARgamma target genes in primary human adipocytes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of CEBPA
output	[EntityWithAccessionedSequence:R-HSA-381289] CEBPA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens [BlackBoxEvent:R-HSA-977271] Expression of EBF1 - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-390510] Positive gene expression regulation by 'EBF1 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-560533] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-976198] Negative gene expression regulation by 'WNT1,WNT10B [extracellular region]' [NegativeGeneExpressionRegulation:R-HSA-976204] Negative gene expression regulation by 'TNF(77-233) [extracellular region]' [NegativeGeneExpressionRegulation:R-HSA-976237] Negative gene expression regulation by 'TGFB1 [extracellular region]'
regulationReference	[RegulationReference:9641879] Negative gene expression regulation by 'TNF(77-233) [extracellular region]' TNF-alpha inhibits 3T3-L1 adipocyte differentiation without downregulating the expression of C/EBPbeta and delta [RegulationReference:9642082] Negative gene expression regulation by 'WNT1,WNT10B [extracellular region]' Inhibition of adipogenesis by Wnt signaling [RegulationReference:9642177] Positive gene expression regulation by 'EBF1 [nucleoplasm]' Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade [RegulationReference:9642395] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' Identification of novel PPARgamma target genes in primary human adipocytes [RegulationReference:9642496] Negative gene expression regulation by 'TGFB1 [extracellular region]' Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-560491
summation	[Summation:560502] The CEBPA gene is transcribed to yield mRNA and the mRNA is ... [Summation:976196] As inferred from mouse, TNF-alpha inhibits expression of CEB... [Summation:976189] As inferred from mouse 3T3-L1 cells, Wnt-1 and Wnt-10b inhib... [Summation:560530] The PPARG:RXRA heterodimer bound to fatty acids activates tr... [Summation:560503] The activation of expression of CEBPA by EBF1 is inferred fr... [Summation:976187] As inferred from mouse, TGF-beta inhibits expression of CEPB...
updateTrackers	[UpdateTracker:9785696] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v51:[addInput] [UpdateTracker:9775501] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v78:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9785696] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v51:[addInput] [UpdateTracker:9775501] Update Tracker - [BlackBoxEvent:560491] Expression of CEBPA - v78:[addSummation]
(precedingEvent)	[BlackBoxEvent:R-HSA-1183032] Expression of GLUT4 [BlackBoxEvent:R-HSA-1183003] Expression of Leptin [BlackBoxEvent:R-HSA-1183058] Expression of Adiponectin
(hasEvent)	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation
(inferredTo)	[BlackBoxEvent:R-MMU-442497] Expression of Cebpa

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