Reactome | Expression of FABP4 (aP2)

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Expression of FABP4 (aP2) Show undefined attributes

authored	[InstanceEdit:556811] May, B, 2010-03-23
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:13977] lipid droplet
created	[InstanceEdit:560489] May, B, 2010-03-24
dbId	560510
displayName	Expression of FABP4 (aP2)
edited	[InstanceEdit:556811] May, B, 2010-03-23
eventOf	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5640172] FABP4 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:560467] A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells [LiteratureReference:560499] Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands [LiteratureReference:560484] Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression [LiteratureReference:2026052] PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of FABP4 (aP2)
output	[EntityWithAccessionedSequence:R-HSA-163428] FABP4 [lipid droplet]
precedingEvent	[Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-390515] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-935998] Positive gene expression regulation by 'CCND3 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-936001] Positive gene expression regulation by 'CDK4 [nucleoplasm]'
regulationReference	[RegulationReference:9641851] Positive gene expression regulation by 'CDK4 [nucleoplasm]' Cdk4 promotes adipogenesis through PPARgamma activation [RegulationReference:9642197] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells [RegulationReference:9643039] Positive gene expression regulation by 'CCND3 [nucleoplasm]' Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-560510
summation	[Summation:560474] The FABP4 gene is transcribed to yield mRNA and the mRNA is ... [Summation:936003] As inferred from mouse, Cdk4 interacts with PPARG and enhanc... [Summation:560466] The PPARG:RXRA heterodimer bound to fatty acids activates tr... [Summation:936007] As inferred from mouse, CyclinD3 interacts with PPARG and en...

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[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation

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