Reactome | Expression of Adiponectin

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Expression of Adiponectin Show undefined attributes

authored	[InstanceEdit:1183020] May, B, 2011-02-08
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:1183014] May, B, 2011-02-09
dbId	1183058
displayName	Expression of Adiponectin
edited	[InstanceEdit:1183020] May, B, 2011-02-08
eventOf	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-8848663] ADIPOQ trimer binds ADIPOR dimers - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5640188] ADIPOQ gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1183036] Identification of a novel distal enhancer in human adiponectin gene [LiteratureReference:1183031] C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer [LiteratureReference:1182993] Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors [LiteratureReference:1182997] Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of Adiponectin
output	[EntityWithAccessionedSequence:R-HSA-1183052] ADIPOQ [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-560491] Expression of CEBPA - Homo sapiens [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens [BlackBoxEvent:R-HSA-381337] Expression of CEBPB in adipogenesis - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1183063] Positive gene expression regulation by 'CEBPA [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1183080] Positive gene expression regulation by 'CEBPB [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1183084] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]'
regulationReference	[RegulationReference:9641763] Positive gene expression regulation by 'CEBPA [nucleoplasm]' Identification of a novel distal enhancer in human adiponectin gene [RegulationReference:9642191] Positive gene expression regulation by 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors [RegulationReference:9642679] Positive gene expression regulation by 'CEBPB [nucleoplasm]' Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1183058
summation	[Summation:1183009] The Adiponectin gene is transcribed to yield mRNA and the mR... [Summation:1183090] C/EBPalpha (CEBPA) binds the promoter of the Adiponectin gen... [Summation:1183066] C/EBPbeta (CEBPB) binds the promoter of the Adiponectin gene... [Summation:1183078] The PPARG:RXRA heterodimer activated by a thiazolidinedione ...
updateTrackers	[UpdateTracker:9775526] Update Tracker - [BlackBoxEvent:1183058] Expression of Adiponectin - v78:[addSummation] [UpdateTracker:9785783] Update Tracker - [BlackBoxEvent:1183058] Expression of Adiponectin - v51:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9775526] Update Tracker - [BlackBoxEvent:1183058] Expression of Adiponectin - v78:[addSummation] [UpdateTracker:9785783] Update Tracker - [BlackBoxEvent:1183058] Expression of Adiponectin - v51:[addInput]
(precedingEvent)	[Reaction:R-HSA-8848663] ADIPOQ trimer binds ADIPOR dimers
(hasEvent)	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation

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