Reactome | EP300 [nucleoplasm]

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EP300 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:9701519] peptide-lysine-N-acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:3662301] histone acetyltransferase activity of EP300 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9029520] EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9038159] ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] - Homo sapiens [Complex:R-HSA-9011883] MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9009369] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] - Homo sapiens [Complex:R-HSA-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter - Homo sapiens [Reaction:R-HSA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter - Homo sapiens [Reaction:R-HSA-3899291] SUMOylation of EP300 with SUMO1 - Homo sapiens [Reaction:R-HSA-5663293] RORA, EP300 bind SREBF1 gene - Homo sapiens [Reaction:R-NUL-9617710] EP300 binds SOH-C477-Foxo4 - Mus musculus [Reaction:R-HSA-5663246] RORA, EP300 bind NPAS2 gene - Homo sapiens [Reaction:R-HSA-6804229] JMY, TTC5 and EP300 bind - Homo sapiens [Reaction:R-HSA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 - Homo sapiens [Reaction:R-HSA-9023884] NCOA1 recruits EP300 to TGFA promoter - Homo sapiens [Reaction:R-HSA-9011981] EP300 is recruited to MYC and BCL2 genes - Homo sapiens [Reaction:R-HSA-5250930] B-WICH recruits histone acetyltransferases - Homo sapiens [Reaction:R-HSA-9617064] SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene - Homo sapiens [BlackBoxEvent:R-HSA-5617452] Retinoic acid activates HOXB1 chromatin - Homo sapiens [Reaction:R-HSA-5663264] RORA, EP300 bind CPT1A gene - Homo sapiens [Reaction:R-HSA-5663273] RORA, EP300, PPARGC1A bind NR1D1 gene - Homo sapiens [Reaction:R-HSA-8878056] RUNX1:CBFB binds EP300 - Homo sapiens [Reaction:R-HSA-8951951] RUNX3 binds EP300 - Homo sapiens [Reaction:R-HSA-3222093] BRD7 binds TP53 and EP300 - Homo sapiens [Reaction:R-HSA-9613451] p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes - Homo sapiens [Reaction:R-HSA-6811479] ING2 recruits EP300 to TP53 - Homo sapiens [Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators - Homo sapiens [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Homo sapiens [Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML - Homo sapiens [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens [BlackBoxEvent:R-HSA-5617896] Retinoic acid activates HOXD4 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617431] Retinoic acid activates HOXA1 chromatin - Homo sapiens [Reaction:R-HSA-9737710] SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter - Homo sapiens [Reaction:R-HSA-2976563] NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter - Homo sapiens [Reaction:R-HSA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP - Homo sapiens [Reaction:R-HSA-4088162] FOXM1 binds CDC25A promoter - Homo sapiens [Reaction:R-HSA-1368087] RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene - Homo sapiens [BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters - Homo sapiens [Reaction:R-HSA-3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter - Homo sapiens [Reaction:R-HSA-9816396] DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene - Homo sapiens [BlackBoxEvent:R-HSA-5617859] Retinoic acid activates HOXB4 chromatin - Homo sapiens [Reaction:R-HSA-8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene - Homo sapiens [Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML - Homo sapiens [Reaction:R-HSA-9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-5617862] Retinoic acid activates HOXA4 chromatin - Homo sapiens [Reaction:R-HSA-8936616] RUNX1 and GATA1 bind the promoter of the GP1BA gene - Homo sapiens [Reaction:R-HSA-8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene - Homo sapiens [Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Homo sapiens [Reaction:R-HSA-9620717] p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter - Homo sapiens [Reaction:R-HSA-9023840] HATs and coactivators are recruited to the CTSD gene - Homo sapiens [Reaction:R-HSA-8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene - Homo sapiens
created	[InstanceEdit:381302] May, B, 2008-11-19 19:18:44
dbId	381325
displayName	EP300 [nucleoplasm]
endCoordinate	2414
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-381325] EP300 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-381325] Ep300 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-381325] EP300 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-381325] EP300 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-381325] EP300 [nucleoplasm] - Sus scrofa [GenomeEncodedEntity:R-DRE-381325] Ghost homologue of EP300 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-381325] ep300 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-381325] EP300 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-381325] nej [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-381325] EP300 [nucleoplasm] - Caenorhabditis elegans [GenomeEncodedEntity:R-DDI-381325] Ghost homologue of EP300 [nucleoplasm] - Dictyostelium discoideum
memberOf	[DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9023862] histone acetyltransferases [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3697937] Jupe, S, 2013-06-10
name	EP300 p300 Histone acetyltransferase p300 EP300_HUMAN KAT3B
negativelyRegulates	[NegativeRegulation:R-HSA-8952420] Negative regulation by 'EP300 [nucleoplasm]'
producedByEvent	[Reaction:R-NUL-9617757] EP300 acetylates Foxo4 - Homo sapiens [Reaction:R-HSA-8952058] CCND1 binds RUNX3 and displaces EP300 - Homo sapiens [Reaction:R-NUL-9617742] TXN disrupts Foxo4 comples with EP300 - Homo sapiens [Reaction:R-HSA-9617735] TXN disrupts FOXO4 complex with EP300 - Homo sapiens [Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants - Homo sapiens [Reaction:R-NUL-2065178] CDK8 phosphorylates xNICD1 - Homo sapiens [Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:61164] UniProt:Q09472 EP300
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-381325
startCoordinate	2

Referrals

(hasComponent)	[Complex:R-HSA-9029520] EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] [Complex:R-HSA-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] [Complex:R-HSA-9011932] BLC2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-HSA-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] [Complex:R-HSA-9038159] ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] [Complex:R-HSA-9008268] ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] [Complex:R-HSA-9011883] MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm] [Complex:R-HSA-9018479] TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-HSA-9018491] FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-HSA-9008249] CITED1:EP300:ESR1:estrogen:TGFA gene promoter [nucleoplasm] [Complex:R-HSA-9023880] ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] [Complex:R-HSA-9011897] MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-HSA-8869505] MYSM1:EP300:KAT2B [nucleoplasm] [Complex:R-HSA-5250942] B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] [Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Complex:R-HSA-381367] PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] [Complex:R-HSA-9816378] DUX4:TPRXL:TPRX1:TPRX2:EP300:CREBBP:ZSCAN4 gene [nucleoplasm] [Complex:R-HSA-9617082] CEBPE gene:EP300:SPI1:PML [nucleoplasm] [Complex:R-HSA-5617888] atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] [Complex:R-HSA-5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] [Complex:R-HSA-5617470] atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] [Complex:R-HSA-5617448] atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] [Complex:R-HSA-5617873] atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] [Complex:R-HSA-5663244] RORA:EP300:CPT1A gene [nucleoplasm] [Complex:R-HSA-5663295] RORA:EP300:SREBF1 gene [nucleoplasm] [Complex:R-HSA-9737700] SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300 [nucleoplasm] [Complex:R-HSA-8878064] RUNX1:CBFB:EP300 [nucleoplasm] [Complex:R-HSA-8936477] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Complex:R-HSA-2976561] NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm] [Complex:R-NUL-2064911] xNOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-HSA-8951952] RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-HSA-8951959] Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-NUL-2065276] mNICD1 Chimeric Enhancer Complex [nucleoplasm] [Complex:R-HSA-8864321] TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] [Complex:R-HSA-4088158] p-T611,S730,S739-FOXM1:EP300:CDC25A Gene [nucleoplasm] [Complex:R-HSA-1368124] RORA:Coactivator [nucleoplasm] [Complex:R-HSA-5663257] RORA:EP300:NPAS2 gene [nucleoplasm] [Complex:R-HSA-9009369] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] [Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-HSA-9733208] (2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm] [Complex:R-HSA-9613448] ID1,ID3 genes:p-S133-CREB1:LYL1:EP300 [nucleoplasm] [Complex:R-HSA-9620695] VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm] [Complex:R-HSA-1234099] HIF:CBP:p300 [nucleoplasm] [Complex:R-HSA-3215149] p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] [Complex:R-HSA-6804233] p-S203,S221-TTC5:EP300:JMY [nucleoplasm] [Complex:R-HSA-3215194] ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-HSA-6811488] ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-HSA-3222096] BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [Complex:R-HSA-5628870] BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm]
(input)	[Reaction:R-HSA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter [Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators [Reaction:R-HSA-9023840] HATs and coactivators are recruited to the CTSD gene [Reaction:R-HSA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter [Reaction:R-HSA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter [Reaction:R-HSA-9023884] NCOA1 recruits EP300 to TGFA promoter [Reaction:R-HSA-9011981] EP300 is recruited to MYC and BCL2 genes [Reaction:R-HSA-3899291] SUMOylation of EP300 with SUMO1 [Reaction:R-HSA-5250930] B-WICH recruits histone acetyltransferases [Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands [Reaction:R-HSA-9816396] DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene [Reaction:R-HSA-9617064] SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene [BlackBoxEvent:R-HSA-5617859] Retinoic acid activates HOXB4 chromatin [BlackBoxEvent:R-HSA-5617896] Retinoic acid activates HOXD4 chromatin [BlackBoxEvent:R-HSA-5617452] Retinoic acid activates HOXB1 chromatin [BlackBoxEvent:R-HSA-5617431] Retinoic acid activates HOXA1 chromatin [BlackBoxEvent:R-HSA-5617862] Retinoic acid activates HOXA4 chromatin [Reaction:R-HSA-5663264] RORA, EP300 bind CPT1A gene [Reaction:R-HSA-5663293] RORA, EP300 bind SREBF1 gene [Reaction:R-HSA-5663273] RORA, EP300, PPARGC1A bind NR1D1 gene [Reaction:R-HSA-9737710] SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter [Reaction:R-NUL-9617710] EP300 binds SOH-C477-Foxo4 [Reaction:R-HSA-8878056] RUNX1:CBFB binds EP300 [Reaction:R-HSA-8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene [Reaction:R-HSA-8936616] RUNX1 and GATA1 bind the promoter of the GP1BA gene [Reaction:R-HSA-8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene [Reaction:R-HSA-8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene [Reaction:R-HSA-2976563] NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter [Reaction:R-HSA-8951951] RUNX3 binds EP300 [Reaction:R-HSA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP [Reaction:R-HSA-3222093] BRD7 binds TP53 and EP300 [Reaction:R-HSA-4088162] FOXM1 binds CDC25A promoter [Reaction:R-HSA-1368087] RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene [Reaction:R-HSA-5663246] RORA, EP300 bind NPAS2 gene [Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter [Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML [Reaction:R-HSA-9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter [Reaction:R-HSA-9613451] p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes [Reaction:R-HSA-9620717] p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter [BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters [Reaction:R-HSA-3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter [Reaction:R-HSA-6804229] JMY, TTC5 and EP300 bind [Reaction:R-HSA-6811479] ING2 recruits EP300 to TP53
(output)	[Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants [Reaction:R-NUL-9617757] EP300 acetylates Foxo4 [Reaction:R-NUL-9617742] TXN disrupts Foxo4 comples with EP300 [Reaction:R-HSA-9617735] TXN disrupts FOXO4 complex with EP300 [Reaction:R-NUL-2065178] CDK8 phosphorylates xNICD1 [Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 [Reaction:R-HSA-8952058] CCND1 binds RUNX3 and displaces EP300
(hasMember)	[DefinedSet:R-HSA-9023862] histone acetyltransferases [nucleoplasm] [DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-5634074] Positive gene expression regulation by 'atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634093] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634091] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634072] Positive gene expression regulation by 'atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634068] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm]' [CatalystActivity:9617762] peptide-lysine-N-acetyltransferase activity of EP300-S-S-Foxo4:Foxo4-S-S-EP300 [nucleoplasm] [PositiveGeneExpressionRegulation:R-HSA-2976565] Positive gene expression regulation by 'NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-4088166] Positive gene expression regulation by 'p-T611,S730,S739-FOXM1:EP300:CDC25A Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9613458] Positive gene expression regulation by 'ID1,ID3 genes:p-S133-CREB1:LYL1:EP300 [nucleoplasm]' [PositiveGeneExpressionRegulation:9620692] Positive gene expression regulation by 'VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-3215147] Positive gene expression regulation by 'p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm]' [CatalystActivity:6811481] peptide-lysine-N-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [CatalystActivity:5628869] acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm]
(physicalEntity)	[CatalystActivity:9701519] peptide-lysine-N-acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:3662301] histone acetyltransferase activity of EP300 [nucleoplasm]
(hasCandidate)	[CandidateSet:R-HSA-9620507] KAT2B,(EP300) [nucleoplasm]
(regulator)	[NegativeRegulation:R-HSA-8952420] Negative regulation by 'EP300 [nucleoplasm]'

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