Reactome | Transcriptional regulation of white adipocyte differentiation

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Transcriptional regulation of white adipocyte differentiation Show undefined attributes

authored	[InstanceEdit:420926] May, B, 2009-05-15 01:13:47
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:381302] May, B, 2008-11-19 19:18:44
dbId	381340
displayName	Transcriptional regulation of white adipocyte differentiation
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf	[Pathway:R-HSA-9843745] Adipogenesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161436] white fat cell differentiation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-381337] Expression of CEBPB in adipogenesis - Homo sapiens [BlackBoxEvent:R-HSA-977392] Expression of CEBPD - Homo sapiens [BlackBoxEvent:R-HSA-381377] Expression of KLF5 - Homo sapiens [BlackBoxEvent:R-HSA-977271] Expression of EBF1 - Homo sapiens [BlackBoxEvent:R-HSA-381283] Expression of PPARG - Homo sapiens [Reaction:R-HSA-381262] Formation of PPARG:RXRA heterodimer (ARF6 complex) - Homo sapiens [Reaction:R-HSA-381290] PPARG:RXRA heterodimer binds to PPARG corepressors - Homo sapiens [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens [Reaction:R-HSA-9732629] PPARG binds PPARG agonists - Homo sapiens [BlackBoxEvent:R-HSA-560510] Expression of FABP4 (aP2) - Homo sapiens [BlackBoxEvent:R-HSA-560493] Expression of Perilipin (PLIN) - Homo sapiens [BlackBoxEvent:R-HSA-560472] Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) - Homo sapiens [BlackBoxEvent:R-HSA-560473] Expression of ANGPTL4 - Homo sapiens [BlackBoxEvent:R-HSA-560498] Expression of Lipoprotein lipase (LPL) - Homo sapiens [BlackBoxEvent:R-HSA-560491] Expression of CEBPA - Homo sapiens [BlackBoxEvent:R-HSA-560517] Expression of CD36 (platelet glycoprotein IV, FAT) - Homo sapiens [BlackBoxEvent:R-HSA-1183003] Expression of Leptin - Homo sapiens [BlackBoxEvent:R-HSA-1183058] Expression of Adiponectin - Homo sapiens [BlackBoxEvent:R-HSA-1183032] Expression of GLUT4 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:381232] Fat and beyond: the diverse biology of PPARgamma [LiteratureReference:381354] Transcriptional control of adipocyte formation [LiteratureReference:381324] Developmental origin of fat: tracking obesity to its source [LiteratureReference:381247] PPARs: therapeutic targets for metabolic disease [LiteratureReference:381292] PPARgamma in human and mouse physiology [LiteratureReference:381379] Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology [LiteratureReference:381274] Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha [LiteratureReference:560478] Identification of novel PPARgamma target genes in primary human adipocytes [LiteratureReference:977272] Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation [LiteratureReference:977281] Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells [LiteratureReference:977282] Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins [LiteratureReference:381236] Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade [LiteratureReference:381260] Kr�ppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation [LiteratureReference:1183049] Adipocyte differentiation from the inside out [LiteratureReference:1182994] Human SGBS cells - a unique tool for studies of human fat cell biology [LiteratureReference:1182990] The generation and the manipulation of human multipotent adipose-derived stem cells
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Transcriptional regulation of white adipocyte differentiation
orthologousEvent	[Pathway:R-MMU-381340] Transcriptional regulation of white adipocyte differentiation - Mus musculus [Pathway:R-RNO-381340] Transcriptional regulation of white adipocyte differentiation - Rattus norvegicus [Pathway:R-CFA-381340] Transcriptional regulation of white adipocyte differentiation - Canis familiaris [Pathway:R-BTA-381340] Transcriptional regulation of white adipocyte differentiation - Bos taurus [Pathway:R-SSC-381340] Transcriptional regulation of white adipocyte differentiation - Sus scrofa [Pathway:R-DRE-381340] Transcriptional regulation of white adipocyte differentiation - Danio rerio [Pathway:R-GGA-381340] Transcriptional regulation of white adipocyte differentiation - Gallus gallus [Pathway:R-DME-381340] Transcriptional regulation of white adipocyte differentiation - Drosophila melanogaster
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-381340
summation	[Summation:381278] Adipogenesis is the process of cell differentiation by which...
updateTrackers	[UpdateTracker:9782705] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v58:[updateContainedRLE] [UpdateTracker:9787809] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v44:[updateContainedRLE] [UpdateTracker:9788932] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v39:[updateContainedRLE] [UpdateTracker:9787256] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v46:[modifyText, updateContainedRLE] [UpdateTracker:9785928] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v51:[updateContainedRLE] [UpdateTracker:9779348] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v65:[updateContainedRLE] [UpdateTracker:9779950] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v64:[updateContainedRLE] [UpdateTracker:9783077] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v57:[removeHasEvent, updateContainedRLE] [UpdateTracker:9782078] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v59:[updateContainedRLE] [UpdateTracker:9774673] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v81:[addHasEvent] [UpdateTracker:9788807] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v40:[updateContainedRLE] [UpdateTracker:9775814] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v78:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-9843745] Adipogenesis

(updatedInstance)

[UpdateTracker:9782705] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v58:[updateContainedRLE]
[UpdateTracker:9787809] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v44:[updateContainedRLE]
[UpdateTracker:9788932] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v39:[updateContainedRLE]
[UpdateTracker:9787256] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v46:[modifyText, updateContainedRLE]
[UpdateTracker:9785928] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v51:[updateContainedRLE]
[UpdateTracker:9779348] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v65:[updateContainedRLE]
[UpdateTracker:9779950] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v64:[updateContainedRLE]
[UpdateTracker:9783077] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v57:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9782078] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v59:[updateContainedRLE]
[UpdateTracker:9774673] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v81:[addHasEvent]
[UpdateTracker:9788807] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v40:[updateContainedRLE]
[UpdateTracker:9775814] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v78:[updateContainedRLE]

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