Reactome | isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate

Schema > Reaction > Entries

authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
catalystActivity	[CatalystActivity:379599] isoleucine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:379895] D'Eustachio, P, 2008-11-05 23:22:56
dbId	379893
displayName	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
eventOf	[Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-30102] L-Ile [cytosol] [GenomeEncodedEntity:R-HSA-379739] tRNA(Ile) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:379897] Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [GenomeEncodedEntity:R-HSA-379787] Ile-tRNA(Ile) [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-379893
summation	[Summation:379896] IARS (cytosolic aspartyl tRNA synthetase) catalyzes the reac...

(hasEvent)

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