Reactome | methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate

Schema > Reaction > Entries

methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate Show undefined attributes

authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
catalystActivity	[CatalystActivity:379606] methionine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:379999] D'Eustachio, P, 2008-11-06 23:24:17
dbId	379994
displayName	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
eventOf	[Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation - Homo sapiens
followingEvent	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-174390] L-Met [cytosol] [GenomeEncodedEntity:R-HSA-379742] tRNA(Met) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380019] The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [GenomeEncodedEntity:R-HSA-379794] Met-tRNA(Met) [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-379994
summation	[Summation:379975] MARS (cytosolic methionyl tRNA synthetase) catalyzes the rea...

Referrals

(hasEvent)	[Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation
(precedingEvent)	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex

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