Reactome | lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate

Schema > Reaction > Entries

authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
catalystActivity	[CatalystActivity:379563] lysine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:379999] D'Eustachio, P, 2008-11-06 23:24:17
dbId	380008
displayName	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
eventOf	[Pathway:R-HSA-379716] Cytosolic tRNA aminoacylation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-351979] L-Lys [cytosol] [GenomeEncodedEntity:R-HSA-379776] tRNA(Lys) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:379986] Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [GenomeEncodedEntity:R-HSA-379736] Lys-tRNA(Lys) [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-380008
summation	[Summation:380045] KARS (cytosolic lysyl tRNA synthetase) catalyzes the reactio...

(hasEvent)

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