Reactome | CBY1 binds beta-catenin

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CBY1 binds beta-catenin Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3769382] Rothfels, K, 2013-06-19
dbId	3769383
displayName	CBY1 binds beta-catenin
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
followingEvent	[Reaction:R-HSA-3769394] AKT phosphorylates CBY1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3769210] CBY1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3769222] Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway [LiteratureReference:3769219] Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity [LiteratureReference:3769245] Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling [LiteratureReference:5323435] Inactivation of Chibby affects function of motile airway cilia
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CBY1 binds beta-catenin
orthologousEvent	[Reaction:R-DME-3769383] CBY1 binds beta-catenin - Drosophila melanogaster [Reaction:R-GGA-3769383] CBY1 binds beta-catenin - Gallus gallus [Reaction:R-XTR-3769383] CBY1 binds beta-catenin - Xenopus tropicalis [Reaction:R-DRE-3769383] CBY1 binds beta-catenin - Danio rerio [Reaction:R-BTA-3769383] CBY1 binds beta-catenin - Bos taurus [Reaction:R-CFA-3769383] CBY1 binds beta-catenin - Canis familiaris [Reaction:R-RNO-3769383] CBY1 binds beta-catenin - Rattus norvegicus [Reaction:R-MMU-3769383] CBY1 binds beta-catenin - Mus musculus
output	[Complex:R-HSA-3769380] CBY1:CTNNB1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3769383
summation	[Summation:3769381] Chibby (CBY1) is a conserved 126 amino acid protein that act...

Referrals

(hasEvent)	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)	[Reaction:R-HSA-3769394] AKT phosphorylates CBY1