Reactome | Deactivation of the beta-catenin transactivating complex

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Deactivation of the beta-catenin transactivating complex Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224547
displayName	Deactivation of the beta-catenin transactivating complex
eventOf	[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-3322431] XIAP binds TLE - Rattus norvegicus [Reaction:R-RNO-3322429] XIAP monoubiquinates TLE - Rattus norvegicus [Reaction:R-RNO-3322434] XIAP dissociates from ub-TLE - Rattus norvegicus [BlackBoxEvent:R-RNO-3364042] APC promotes disassembly of beta-catenin transactivation complex - Rattus norvegicus [BlackBoxEvent:R-RNO-3361751] beta-catenin is replaced by repression complexes at the promoter - Rattus norvegicus [Reaction:R-RNO-3769383] CBY1 binds beta-catenin - Rattus norvegicus [Reaction:R-RNO-3769394] AKT phosphorylates CBY1 - Rattus norvegicus [Reaction:R-RNO-3769393] YWHAZ binds p-CBY:CTNNB1 - Rattus norvegicus [Reaction:R-RNO-3769391] XPO1 binds the beta-catenin:CBY complex - Rattus norvegicus [BlackBoxEvent:R-RNO-3769392] YWHAZ and XPO1 mediate the nuclear export of beta-catenin - Rattus norvegicus [Reaction:R-RNO-3772430] CTNNBIP1 binds beta-catenin - Rattus norvegicus [Reaction:R-RNO-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression - Rattus norvegicus [Reaction:R-RNO-5626938] Beta-catenin binds SOX proteins - Rattus norvegicus [Reaction:R-RNO-5665608] TCF:Beta-catenin binds SOX proteins - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Deactivation of the beta-catenin transactivating complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3769402
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex

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