Reactome | CTNNBIP1 binds beta-catenin

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CTNNBIP1 binds beta-catenin Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3772429] Rothfels, K, 2013-06-24
dbId	3772430
displayName	CTNNBIP1 binds beta-catenin
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3772388] CTNNBIP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3772347] ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules [LiteratureReference:3772348] Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein [LiteratureReference:3772370] The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CTNNBIP1 binds beta-catenin
orthologousEvent	[Reaction:R-GGA-3772430] CTNNBIP1 binds beta-catenin - Gallus gallus [Reaction:R-DRE-3772430] CTNNBIP1 binds beta-catenin - Danio rerio [Reaction:R-SSC-3772430] CTNNBIP1 binds beta-catenin - Sus scrofa [Reaction:R-BTA-3772430] CTNNBIP1 binds beta-catenin - Bos taurus [Reaction:R-CFA-3772430] CTNNBIP1 binds beta-catenin - Canis familiaris [Reaction:R-RNO-3772430] CTNNBIP1 binds beta-catenin - Rattus norvegicus [Reaction:R-MMU-3772430] CTNNBIP1 binds beta-catenin - Mus musculus
output	[Complex:R-HSA-3772415] CTNNBIP1:CTNNB1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3772430
summation	[Summation:3772428] CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein th...

Referrals

(hasEvent)

[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex