Reactome | XIAP binds TLE

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XIAP binds TLE Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3322430] Rothfels, K, 2013-05-03
dbId	3322431
displayName	XIAP binds TLE
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
followingEvent	[Reaction:R-HSA-3322429] XIAP monoubiquinates TLE - Homo sapiens
input	[DefinedSet:R-HSA-3299565] TLE tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3322366] XIAP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3322356] XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling [LiteratureReference:3322311] A novel role for XIAP in copper homeostasis through regulation of MURR1 [LiteratureReference:3322355] XIAP as a ubiquitin ligase in cellular signaling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	XIAP binds TLE
negativePrecedingEvent	[NegativePrecedingEvent:9965516] Futile Cycle: XIAP dissociates from ub-TLE
orthologousEvent	[Reaction:R-DME-3322431] XIAP binds TLE - Drosophila melanogaster [Reaction:R-GGA-3322431] XIAP binds TLE - Gallus gallus [Reaction:R-DRE-3322431] XIAP binds TLE - Danio rerio [Reaction:R-SSC-3322431] XIAP binds TLE - Sus scrofa [Reaction:R-BTA-3322431] XIAP binds TLE - Bos taurus [Reaction:R-CFA-3322431] XIAP binds TLE - Canis familiaris [Reaction:R-RNO-3322431] XIAP binds TLE - Rattus norvegicus [Reaction:R-MMU-3322431] XIAP binds TLE - Mus musculus
output	[Complex:R-HSA-3322390] TLE:XIAP [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3322431
summation	[Summation:3322428] XIAP (X-linked inhibitor of apoptosis) has three BIR domains...

Referrals

(hasEvent)	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)	[Reaction:R-HSA-3322429] XIAP monoubiquinates TLE