Reactome | APC promotes disassembly of beta-catenin transactivation complex

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APC promotes disassembly of beta-catenin transactivation complex Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3364043] Rothfels, K, 2013-05-13
dbId	3364042
displayName	APC promotes disassembly of beta-catenin transactivation complex
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3361751] beta-catenin is replaced by repression complexes at the promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3361755] APC [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3361753] BTRC [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212372] CTBP1 [nucleoplasm] [Complex:R-HSA-3361369] TCF/LEF:CTNNB1:BCL9:PYGO:MLL2:MEN1 complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes [LiteratureReference:3361761] The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF [LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function [LiteratureReference:3364040] Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex [LiteratureReference:3364036] Nuclear APC
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	APC promotes disassembly of beta-catenin transactivation complex
orthologousEvent	[BlackBoxEvent:R-RNO-3364042] APC promotes disassembly of beta-catenin transactivation complex - Rattus norvegicus
output	[DefinedSet:R-HSA-3305844] BCL9 [nucleoplasm] [Complex:R-HSA-9818683] MLL2 complex:MEN1 [nucleoplasm] [DefinedSet:R-HSA-3322379] PYGO [nucleoplasm] [Complex:R-HSA-3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3364014] Recruitment of MLL2 methyltransferase complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22 [InstanceEdit:9971596] D'Eustachio, Peter, 2025-11-07
revised	[InstanceEdit:9965497] Orlic-Milacic, Marija, 2025-08-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3364042
summation	[Summation:3361764] Studies in mouse myoblast and colorectal cancer cell lines s...
updateTrackers	[UpdateTracker:9971803] Update Tracker - [BlackBoxEvent:3364042] APC promotes disassembly of beta-catenin transactivation complex - v95:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9971803] Update Tracker - [BlackBoxEvent:3364042] APC promotes disassembly of beta-catenin transactivation complex - v95:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)	[BlackBoxEvent:R-HSA-3361751] beta-catenin is replaced by repression complexes at the promoter [NegativePrecedingEvent:9965534] Futile Cycle: APC promotes disassembly of beta-catenin transactivation complex [NegativePrecedingEvent:9965525] Futile Cycle: APC promotes disassembly of beta-catenin transactivation complex