Reactome | Beta-catenin binds SOX proteins

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Beta-catenin binds SOX proteins Show undefined attributes

authored	[InstanceEdit:5625833] Garapati, P V, 2014-10-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5626930] Garapati, P V, 2014-10-13
dbId	5626938
displayName	Beta-catenin binds SOX proteins
edited	[InstanceEdit:5625833] Garapati, P V, 2014-10-08
eventOf	[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm] [DefinedSet:R-HSA-5626912] SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5627697] Human SRY inhibits beta-catenin-mediated transcription [LiteratureReference:5627694] Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells [LiteratureReference:5626931] Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin [LiteratureReference:5627708] SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling [LiteratureReference:5627714] Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells [LiteratureReference:5627716] Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13 [LiteratureReference:5626924] SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation [LiteratureReference:5626935] Interactions between Sox9 and beta-catenin control chondrocyte differentiation [LiteratureReference:5665597] Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium [LiteratureReference:5626909] Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus [LiteratureReference:5665592] The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer [LiteratureReference:5665606] ?-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Beta-catenin binds SOX proteins
orthologousEvent	[Reaction:R-CEL-5626938] Beta-catenin binds SOX proteins - Caenorhabditis elegans [Reaction:R-DME-5626938] Beta-catenin binds SOX proteins - Drosophila melanogaster [Reaction:R-GGA-5626938] Beta-catenin binds SOX proteins - Gallus gallus [Reaction:R-XTR-5626938] Beta-catenin binds SOX proteins - Xenopus tropicalis [Reaction:R-DRE-5626938] Beta-catenin binds SOX proteins - Danio rerio [Reaction:R-SSC-5626938] Beta-catenin binds SOX proteins - Sus scrofa [Reaction:R-BTA-5626938] Beta-catenin binds SOX proteins - Bos taurus [Reaction:R-CFA-5626938] Beta-catenin binds SOX proteins - Canis familiaris [Reaction:R-RNO-5626938] Beta-catenin binds SOX proteins - Rattus norvegicus [Reaction:R-MMU-5626938] Beta-catenin binds SOX proteins - Mus musculus
output	[Complex:R-HSA-5626915] CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5674211] Zorn, Aaron M, Harley, Vincent, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5626938
summation	[Summation:5626919] SOX protein family members are the transcription factors tha...

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(hasEvent)

[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex

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