Reactome | Activation of Rap1 by membrane-associated GEFs

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Activation of Rap1 by membrane-associated GEFs Show undefined attributes

authored	[InstanceEdit:939264] Jupe, S, 2010-09-01
catalystActivity	[CatalystActivity:939267] guanyl-nucleotide exchange factor activity of Rap1 cAMP-GEFs [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643423] guanyl-nucleotide exchange factor activity of Rap1 cAMP-GEFs [plasma membrane] CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:939266] Jupe, S, 2010-09-01
dbId	939265
displayName	Activation of Rap1 by membrane-associated GEFs
edited	[InstanceEdit:939264] Jupe, S, 2010-09-01
eventOf	[Pathway:R-HSA-354192] Integrin signaling - Homo sapiens [Pathway:R-HSA-392517] Rap1 signalling - Homo sapiens
followingEvent	[Reaction:R-HSA-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Homo sapiens [Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane - Homo sapiens [Reaction:R-HSA-392513] Rap1 signal termination by Rap1GAPs - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-354074] RAP1:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:354167] RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion [LiteratureReference:354139] Rap1 regulation of RIAM and cell adhesion [LiteratureReference:354121] CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation [LiteratureReference:392504] Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Activation of Rap1 by membrane-associated GEFs
orthologousEvent	[Reaction:R-SCE-939265] Activation of Rap1 by membrane-associated GEFs - Saccharomyces cerevisiae [Reaction:R-DDI-939265] Activation of Rap1 by membrane-associated GEFs - Dictyostelium discoideum [Reaction:R-CEL-939265] Activation of Rap1 by membrane-associated GEFs - Caenorhabditis elegans [Reaction:R-DME-939265] Activation of Rap1 by membrane-associated GEFs - Drosophila melanogaster [Reaction:R-GGA-939265] Activation of Rap1 by membrane-associated GEFs - Gallus gallus [Reaction:R-XTR-939265] Activation of Rap1 by membrane-associated GEFs - Xenopus tropicalis [Reaction:R-SSC-939265] Activation of Rap1 by membrane-associated GEFs - Sus scrofa [Reaction:R-BTA-939265] Activation of Rap1 by membrane-associated GEFs - Bos taurus [Reaction:R-CFA-939265] Activation of Rap1 by membrane-associated GEFs - Canis familiaris [Reaction:R-RNO-939265] Activation of Rap1 by membrane-associated GEFs - Rattus norvegicus [Reaction:R-MMU-939265] Activation of Rap1 by membrane-associated GEFs - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-354126] RAP1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-392834] Activation of EPACs by cAMP - Homo sapiens [Reaction:R-HSA-392831] Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-939265
summation	[Summation:354094] Signals from agonist receptors (such as GPVI) trigger the pr...

Referrals

(hasEvent)	[Pathway:R-HSA-392517] Rap1 signalling [Pathway:R-HSA-354192] Integrin signaling
(precedingEvent)	[Reaction:R-HSA-392835] Rap1 sequesters Raf1 to inhibit ERK cascade [Reaction:R-HSA-392513] Rap1 signal termination by Rap1GAPs [Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane

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