Reactome | Release of CSK from SRC

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Release of CSK from SRC Show undefined attributes

authored	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:377642] Garapati, P V, 2008-09-15 18:46:55
dbId	377644
displayName	Release of CSK from SRC
edited	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
eventOf	[Pathway:R-HSA-354192] Integrin signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1 - Homo sapiens
input	[Complex:R-HSA-377619] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1215943] CSK: a protein-tyrosine kinase involved in regulation of src family kinases [LiteratureReference:377572] Integrins and Src: dynamic duo of adhesion signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Release of CSK from SRC
orthologousEvent	[Reaction:R-CEL-377644] Release of CSK from SRC - Caenorhabditis elegans [Reaction:R-GGA-377644] Release of CSK from SRC - Gallus gallus [Reaction:R-XTR-377644] Release of CSK from SRC - Xenopus tropicalis [Reaction:R-DRE-377644] Release of CSK from SRC - Danio rerio [Reaction:R-SSC-377644] Release of CSK from SRC - Sus scrofa [Reaction:R-BTA-377644] Release of CSK from SRC - Bos taurus [Reaction:R-CFA-377644] Release of CSK from SRC - Canis familiaris [Reaction:R-RNO-377644] Release of CSK from SRC - Rattus norvegicus [Reaction:R-MMU-377644] Release of CSK from SRC - Mus musculus
output	2 × [EntityWithAccessionedSequence:R-HSA-203776] CSK [cytosol] [Complex:R-HSA-377616] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane]
precedingEvent	[Reaction:R-HSA-377641] Clustering of Integrin alphaIIb beta3 complexes - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-377644
summation	[Summation:377571] CSK bound to integrin alphaIIb beta3 negatively regulates SR...
updateTrackers	[UpdateTracker:9790214] Update Tracker - [Reaction:377644] Release of CSK from SRC - v34:[modifyText] [UpdateTracker:9789926] Update Tracker - [Reaction:377644] Release of CSK from SRC - v36:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790214] Update Tracker - [Reaction:377644] Release of CSK from SRC - v34:[modifyText] [UpdateTracker:9789926] Update Tracker - [Reaction:377644] Release of CSK from SRC - v36:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-354192] Integrin signaling
(precedingEvent)	[Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1