Reactome | Integrin signaling

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Integrin signaling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444298
displayName	Integrin signaling
eventOf	[Pathway:R-BTA-76009] Platelet Aggregation (Plug Formation) - Bos taurus [TopLevelPathway:R-BTA-162582] Signal Transduction - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-354173] Activation of Rap1 by cytosolic GEFs - Bos taurus [Reaction:R-BTA-939265] Activation of Rap1 by membrane-associated GEFs - Bos taurus [Reaction:R-BTA-354060] Translocation of RIAM to plasma membrane - Bos taurus [Reaction:R-BTA-354097] Activation of Talin - Bos taurus [Reaction:R-BTA-354077] Integrin alphaIIb beta3 activation - Bos taurus [Reaction:R-BTA-354149] Interaction of integrin alphaIIb beta3 with Fibrinogen - Bos taurus [Reaction:R-BTA-377641] Clustering of Integrin alphaIIb beta3 complexes - Bos taurus [Reaction:R-BTA-377644] Release of CSK from SRC - Bos taurus [Reaction:R-BTA-377643] Dephosphorylation of inactive SRC by PTPB1 - Bos taurus [Reaction:R-BTA-377640] Autophosphorylation of SRC - Bos taurus [Reaction:R-BTA-354066] Translocation of PTK2 to Focal complexes - Bos taurus [Reaction:R-BTA-354073] Autophosphorylation of PTK2 at Y397 - Bos taurus [Reaction:R-BTA-354124] Phosphorylation of pPTK2 by SRC - Bos taurus [Pathway:R-BTA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins - Bos taurus [Pathway:R-BTA-372708] p130Cas linkage to MAPK signaling for integrins - Bos taurus [Reaction:R-BTA-432110] Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding - Bos taurus [Reaction:R-BTA-432096] Activated integrin alphaIIb beta3 binds SHC1 - Bos taurus [BlackBoxEvent:R-BTA-443905] SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow - Bos taurus [BlackBoxEvent:R-BTA-443910] SHC1 dissociates from integrin alphaIIb beta3 - Bos taurus [Reaction:R-BTA-429415] SYK binds to integrin alphaIIb beta3 - Bos taurus [Reaction:R-BTA-429441] SYK activation by SRC - Bos taurus
inferredFrom	[Pathway:R-HSA-354192] Integrin signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Integrin signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-354192
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-BTA-162582] Signal Transduction [Pathway:R-BTA-76009] Platelet Aggregation (Plug Formation)
(inferredTo)	[Pathway:R-HSA-354192] Integrin signaling

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