Reactome | Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription

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Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:3223202] Orlic-Milacic, M, 2013-03-25
dbId	3223200
displayName	Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs - Homo sapiens [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3200017] CDKN2A gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3222541] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [LiteratureReference:3222577] Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS [LiteratureReference:3229093] Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus [LiteratureReference:3229107] Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription
output	[EntityWithAccessionedSequence:R-HSA-3209105] p16INK4A mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-3223201] Positive regulation by 'KDM6B:Fe2+ [nucleoplasm]' [NegativeRegulation:R-HSA-3772112] Negative regulation by 'CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]'
regulationReference	[RegulationReference:9642424] Negative regulation by 'CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]' Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus [RegulationReference:9642580] Positive regulation by 'KDM6B:Fe2+ [nucleoplasm]' The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3223200
summation	[Summation:3772119] While binding of the PRC1.4 complex to the H3K27Me3 mark on ...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24

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