Reactome | KDM6B demethylates H3K27me3 on p16INK4A promoter

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KDM6B demethylates H3K27me3 on p16INK4A promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3222588] histone H3K27me2/H3K27me3 demethylase activity of KDM6B:Fe2+ [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643450] histone demethylase activity (H3-K27 specific) of KDM6B:Fe2+ [nucleoplasm] The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3222594] Orlic-Milacic, M, 2013-03-25
dbId	3222593
displayName	KDM6B demethylates H3K27me3 on p16INK4A promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [Complex:R-HSA-3222570] CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3222541] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [LiteratureReference:3222577] Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	KDM6B demethylates H3K27me3 on p16INK4A promoter
orthologousEvent	[Reaction:R-DDI-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Dictyostelium discoideum [Reaction:R-DME-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Drosophila melanogaster [Reaction:R-XTR-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Xenopus tropicalis [Reaction:R-DRE-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Danio rerio [Reaction:R-SSC-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Sus scrofa [Reaction:R-BTA-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Bos taurus [Reaction:R-CFA-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Canis familiaris [Reaction:R-RNO-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Rattus norvegicus
output	[Complex:R-HSA-3222592] CDKN2A Gene:Nucleosome [nucleoplasm] 3 × [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8979071] KDM6B binds iron - Homo sapiens [Reaction:R-HSA-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3222593
summation	[Summation:3772117] Histone demethylase KDM6B (JMJD3) demethylates H3K27Me3 mark...
updateTrackers	[UpdateTracker:9777820] Update Tracker - [Reaction:3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - v69:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777820] Update Tracker - [Reaction:3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - v69:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription