Reactome | miR-24 binds p16INK4A and p14ARF mRNAs

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miR-24 binds p16INK4A and p14ARF mRNAs Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3209135] Orlic-Milacic, M, 2013-03-01
dbId	3209151
displayName	miR-24 binds p16INK4A and p14ARF mRNAs
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15 [InstanceEdit:9666043] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX - Homo sapiens [Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3209111] Translation of p14ARF mRNA is inhibited by miR-24 - Homo sapiens [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24 - Homo sapiens
input	[Complex:R-HSA-3209134] miR-24 Nonendonucleolytic RISC [cytosol] [DefinedSet:R-HSA-3209130] p16INK4A/p14ARF mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3209145] p16(INK4a) translation suppressed by miR-24 [LiteratureReference:3209136] Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	miR-24 binds p16INK4A and p14ARF mRNAs
output	[Complex:R-HSA-3209131] p16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISC [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription - Homo sapiens [BlackBoxEvent:R-HSA-3229138] MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription - Homo sapiens [BlackBoxEvent:R-HSA-3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - Homo sapiens [BlackBoxEvent:R-HSA-3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:9666044] Vegi, Naidu M, 2019-10-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3209151
summation	[Summation:3245946] MicroRNA miR-24 is able to bind both p16INK4A mRNA (Lal et a...
updateTrackers	[UpdateTracker:9777822] Update Tracker - [Reaction:3209151] miR-24 binds p16INK4A and p14ARF mRNAs - v69:[modifyText]

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(updatedInstance)	[UpdateTracker:9777822] Update Tracker - [Reaction:3209151] miR-24 binds p16INK4A and p14ARF mRNAs - v69:[modifyText]
(hasEvent)	[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-2559585] Oncogene Induced Senescence
(precedingEvent)	[BlackBoxEvent:R-HSA-3209111] Translation of p14ARF mRNA is inhibited by miR-24 [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24