Reactome | Negative regulation by 'CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]'

Schema > NegativeRegulation > Entries

activeUnit	[Complex:R-HSA-3229073] PRC1.4 [nucleoplasm] - Homo sapiens
created	[InstanceEdit:3772111] Orlic-Milacic, M, 2013-06-24
dbId	3772112
displayName	Negative regulation by 'CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription - Homo sapiens
regulator	[Complex:R-HSA-3229098] CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]
schemaClass	NegativeRegulation
stId	R-HSA-3772112

(regulation)	[RegulationReference:9642424] Negative regulation by 'CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]' Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
(regulatedBy)	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription

Cite Us!