Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription

Stable Identifier
R-HSA-3223200
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription
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While binding of the PRC1.4 complex to the H3K27Me3 mark on the promoter of p16INK4A inhibits p16INK4A transcription (Dietrich et al. 2007, Agherbi et al. 2009), KDM6B-mediated demethylation of lysine 28 of histone HIST1H3A (the removal of H3K27Me3 mark) stimulates p16INK4A transcription (Agger et al. 2009, Barradas et al. 2009).
Literature References
PubMed ID Title Journal Year
19451217 The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

Helin, K, Rudkjaer, L, Christensen, J, Andersen, G, Agger, K, Williams, K, Cloos, PA

Genes Dev. 2009
17332741 Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

Helin, K, Schjerling, CK, Dietrich, N, Koseki, H, Bracken, AP, Hansen, KH, Rappsilber, J, Trinh, E

EMBO J. 2007
19462008 Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

Agherbi, H, Serrano, M, Chasson, L, Verthuy, C, Djabali, M, Gaussmann-Wenger, A

PLoS ONE 2009
19451218 Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

Peters, G, Banck, M, Zhou, MM, Gil, J, Walsh, MJ, Li, S, Maertens, G, Acosta, JC, Barradas, M, Anderton, E, Rodriguez-Niedenführ, M, Banito, A

Genes Dev. 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
Active Unit
PRC1.4 [nucleoplasm]
Positively by
Regulator
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-25)
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