Reactome | Positive regulation by 'KDM6B:Fe2+ [nucleoplasm]'

Schema > PositiveRegulation > Entries

created	[InstanceEdit:3223202] Orlic-Milacic, M, 2013-03-25
dbId	3223201
displayName	Positive regulation by 'KDM6B:Fe2+ [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription - Homo sapiens
regulator	[Complex:R-HSA-3222589] KDM6B:Fe2+ [nucleoplasm]
schemaClass	PositiveRegulation
stId	R-HSA-3223201

(regulation)	[RegulationReference:9642580] Positive regulation by 'KDM6B:Fe2+ [nucleoplasm]' The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
(regulatedBy)	[BlackBoxEvent:R-HSA-3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription

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