Reactome | Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6

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Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730861
displayName	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Homo sapiens
input	[Complex:R-HSA-2685691] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] [Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208244] TAK1-dependent signaling requires functional interaction with TAB2/TAB3 [LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains [LiteratureReference:208287] TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
orthologousEvent	[Reaction:R-GGA-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Gallus gallus [Reaction:R-XTR-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Xenopus tropicalis [Reaction:R-SSC-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Sus scrofa [Reaction:R-BTA-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Bos taurus [Reaction:R-CFA-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Canis familiaris [Reaction:R-RNO-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Rattus norvegicus [Reaction:R-MMU-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Mus musculus
output	[Complex:R-HSA-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2730904] Auto-ubiquitination of TRAF6 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730861
summation	[Summation:2685561] K-63 linked polyubiquitin (pUb) chain on TRAF6 provides a sc...

Referrals

(hasEvent)	[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation
(precedingEvent)	[BlackBoxEvent:R-HSA-2730900] Activation of TAK1 complex bound to pUb-TRAF6