Reactome | Activation of TAK1 complex bound to pUb-TRAF6

Schema > BlackBoxEvent > Entries

Activation of TAK1 complex bound to pUb-TRAF6 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2730901] protein serine/threonine kinase activity of DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643631] protein serine/threonine kinase activity of DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730907] Garapati, P V, 2012-12-05
dbId	2730900
displayName	Activation of TAK1 complex bound to pUb-TRAF6
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation - Homo sapiens
followingEvent	[Reaction:R-HSA-2730876] Phosphorylation of IKK-beta by TAK1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop [LiteratureReference:2586636] Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of TAK1 complex bound to pUb-TRAF6
orthologousEvent	[BlackBoxEvent:R-GGA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Gallus gallus [BlackBoxEvent:R-XTR-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Xenopus tropicalis [BlackBoxEvent:R-SSC-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Sus scrofa [BlackBoxEvent:R-BTA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Bos taurus [BlackBoxEvent:R-CFA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Canis familiaris [BlackBoxEvent:R-RNO-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Rattus norvegicus [BlackBoxEvent:R-MMU-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2685709] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2730900
summation	[Summation:2685555] Binding of TAB2 and TAB3 to K63-linked polyubiquitin chains ...

Referrals

(hasEvent)	[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation
(precedingEvent)	[Reaction:R-HSA-2730876] Phosphorylation of IKK-beta by TAK1