Reactome | p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB

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p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202546] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202550] Garapati, P V, 2007-11-01 14:13:20
dbId	202541
displayName	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
eventOf	[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation - Homo sapiens [Pathway:R-HSA-202424] Downstream TCR signaling - Homo sapiens [Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex - Homo sapiens [Reaction:R-HSA-193691] NF-kB migrates to the nucleus and turns on transcription - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-193938] IkB(alpha):NF-kB complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685277] Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity [LiteratureReference:193933] A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB [LiteratureReference:202558] Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways [LiteratureReference:202539] Signaling to NF-kappaB [LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
orthologousEvent	[Reaction:R-DME-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Drosophila melanogaster [Reaction:R-GGA-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Gallus gallus [Reaction:R-SSC-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Sus scrofa [Reaction:R-BTA-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Bos taurus [Reaction:R-RNO-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Rattus norvegicus [Reaction:R-MMU-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-202534] Ubiquitination of NEMO by TRAF6 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202541
summation	[Summation:202540] NF-kB is sequestered in the cytosol of unstimulated cells th...
updateTrackers	[UpdateTracker:9787446] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v45:[add_removeOutput] [UpdateTracker:9786324] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v50:[add_removeOutput] [UpdateTracker:9787707] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v44:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787446] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v45:[add_removeOutput] [UpdateTracker:9786324] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v50:[add_removeOutput] [UpdateTracker:9787707] Update Tracker - [Reaction:202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - v44:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling [Pathway:R-HSA-2871837] FCERI mediated NF-kB activation [Pathway:R-HSA-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-HSA-193691] NF-kB migrates to the nucleus and turns on transcription [BlackBoxEvent:R-HSA-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex

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