Reactome | Phase I - Functionalization of compounds

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Phase I - Functionalization of compounds Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:17906] mitochondrial outer membrane [Compartment:5460] mitochondrial matrix [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
dbId	211945
diseasePathways	[Pathway:R-HSA-5579000] Defective CYP1B1 causes Glaucoma - Homo sapiens [Pathway:R-HSA-5579004] Defective CYP26C1 causes FFDD4 - Homo sapiens [Pathway:R-HSA-5579005] Defective CYP4F22 causes ARCI5 - Homo sapiens [Pathway:R-HSA-5579019] Defective FMO3 causes TMAU - Homo sapiens [Pathway:R-HSA-5579017] Defective CYP11B1 causes AH4 - Homo sapiens [Pathway:R-HSA-5579021] Defective CYP21A2 causes AH3 - Homo sapiens [Pathway:R-HSA-5579010] Defective CYP24A1 causes HCAI - Homo sapiens [Pathway:R-HSA-5579011] Defective CYP2U1 causes SPG56 - Homo sapiens [Pathway:R-HSA-5579009] Defective CYP11B2 causes CMO-1 deficiency - Homo sapiens [Pathway:R-HSA-5579015] Defective CYP26B1 causes RHFCA - Homo sapiens [Pathway:R-HSA-5579012] Defective MAOA causes BRUNS - Homo sapiens [Pathway:R-HSA-5579013] Defective CYP7B1 causes SPG5A and CBAS3 - Homo sapiens [Pathway:R-HSA-5579032] Defective TBXAS1 causes GHDD - Homo sapiens [Pathway:R-HSA-5579026] Defective CYP11A1 causes AICSR - Homo sapiens [Pathway:R-HSA-5579030] Defective CYP19A1 causes AEXS - Homo sapiens
displayName	Phase I - Functionalization of compounds
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211859] Biological oxidations - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type - Homo sapiens [Pathway:R-HSA-217271] FMO oxidises nucleophiles - Homo sapiens [Pathway:R-HSA-140180] COX reactions - Homo sapiens [Pathway:R-HSA-140179] Amine Oxidase reactions - Homo sapiens [Pathway:R-HSA-71384] Ethanol oxidation - Homo sapiens [Reaction:R-HSA-5692283] ALD3A1 oxidises 4HPCP to CXPA - Homo sapiens [Reaction:R-HSA-5693691] CES1 trimer.CES2 hydrolyse COCN to BEG - Homo sapiens [Reaction:R-HSA-5694077] EPHX1 hydrates BaP4,5O to BaP4,5-DHD - Homo sapiens [Reaction:R-HSA-5696131] AOC1 deaminates Hist - Homo sapiens [Reaction:R-HSA-5696146] AOC2 deaminates TYR - Homo sapiens [Reaction:R-HSA-5696183] AOC3 deaminates BZAM - Homo sapiens [Reaction:R-HSA-5689000] AADAC deacetylates PHEN - Homo sapiens [Reaction:R-HSA-6784959] BPHL hydrolyses VACV to ACV - Homo sapiens [Reaction:R-HSA-6786190] CMBL hydrolyses OM to OLMS - Homo sapiens [Reaction:R-HSA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Homo sapiens [Reaction:R-HSA-8936519] NQO2:FAD dimer reduces quinones to hydroquinones - Homo sapiens [Reaction:R-HSA-8937419] CBR3 reduces DOX to DOXOL - Homo sapiens [Reaction:R-HSA-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Homo sapiens [Pathway:R-HSA-8937144] Aryl hydrocarbon receptor signalling - Homo sapiens [Reaction:R-HSA-9678766] CYP3A4 binds CYP3A4 inhibitors - Homo sapiens [Reaction:R-HSA-9680865] CYP3A4, CYP2B6 bind ritonavir - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:266270] Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics [LiteratureReference:266174] Cytochrome P450s and other enzymes in drug metabolism and toxicity [LiteratureReference:266241] The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
maxDepth	5
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Phase I - Functionalization of compounds
orthologousEvent	[Pathway:R-MMU-211945] Phase I - Functionalization of compounds - Mus musculus [Pathway:R-RNO-211945] Phase I - Functionalization of compounds - Rattus norvegicus [Pathway:R-CFA-211945] Phase I - Functionalization of compounds - Canis familiaris [Pathway:R-BTA-211945] Phase I - Functionalization of compounds - Bos taurus [Pathway:R-SSC-211945] Phase I - Functionalization of compounds - Sus scrofa [Pathway:R-DRE-211945] Phase I - Functionalization of compounds - Danio rerio [Pathway:R-XTR-211945] Phase I - Functionalization of compounds - Xenopus tropicalis [Pathway:R-GGA-211945] Phase I - Functionalization of compounds - Gallus gallus [Pathway:R-DME-211945] Phase I - Functionalization of compounds - Drosophila melanogaster [Pathway:R-CEL-211945] Phase I - Functionalization of compounds - Caenorhabditis elegans [Pathway:R-DDI-211945] Phase I - Functionalization of compounds - Dictyostelium discoideum [Pathway:R-SPO-211945] Phase I - Functionalization of compounds - Schizosaccharomyces pombe [Pathway:R-SCE-211945] Phase I - Functionalization of compounds - Saccharomyces cerevisiae [Pathway:R-PFA-211945] Phase I - Functionalization of compounds - Plasmodium falciparum
releaseDate	2008-06-30
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-211945
summation	[Summation:76366] Phase 1 of metabolism is concerned with functionalizat...
updateTrackers	[UpdateTracker:9786590] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v49:[updateContainedPathway] [UpdateTracker:9790558] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v33:[updateContainedPathway] [UpdateTracker:9785858] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v51:[updateContainedPathway] [UpdateTracker:9783567] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v56:[updateContainedPathway] [UpdateTracker:9842219] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v86:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9778732] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v67:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9774727] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v81:[addHasEvent, updateContainedPathway] [UpdateTracker:9784490] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9786245] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v50:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791021] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v32:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782426] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9783996] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v55:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781966] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v60:[updateIndirectRLE] [UpdateTracker:9791653] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v28:[updateIndirectRLE] [UpdateTracker:9788331] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789875] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v37:[updateIndirectRLE] [UpdateTracker:9788527] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v41:[updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-211859] Biological oxidations
(normalPathway)	[Pathway:R-HSA-5579000] Defective CYP1B1 causes Glaucoma [Pathway:R-HSA-5579004] Defective CYP26C1 causes FFDD4 [Pathway:R-HSA-5579005] Defective CYP4F22 causes ARCI5 [Pathway:R-HSA-5579019] Defective FMO3 causes TMAU [Pathway:R-HSA-5579017] Defective CYP11B1 causes AH4 [Pathway:R-HSA-5579021] Defective CYP21A2 causes AH3 [Pathway:R-HSA-5579010] Defective CYP24A1 causes HCAI [Pathway:R-HSA-5579011] Defective CYP2U1 causes SPG56 [Pathway:R-HSA-5579009] Defective CYP11B2 causes CMO-1 deficiency [Pathway:R-HSA-5579015] Defective CYP26B1 causes RHFCA [Pathway:R-HSA-5579012] Defective MAOA causes BRUNS [Pathway:R-HSA-5579013] Defective CYP7B1 causes SPG5A and CBAS3 [Pathway:R-HSA-5579032] Defective TBXAS1 causes GHDD [Pathway:R-HSA-5579026] Defective CYP11A1 causes AICSR [Pathway:R-HSA-5579030] Defective CYP19A1 causes AEXS
(updatedInstance)	[UpdateTracker:9786590] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v49:[updateContainedPathway] [UpdateTracker:9790558] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v33:[updateContainedPathway] [UpdateTracker:9785858] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v51:[updateContainedPathway] [UpdateTracker:9783567] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v56:[updateContainedPathway] [UpdateTracker:9842219] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v86:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9778732] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v67:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9774727] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v81:[addHasEvent, updateContainedPathway] [UpdateTracker:9784490] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9786245] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v50:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791021] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v32:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782426] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9783996] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v55:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781966] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v60:[updateIndirectRLE] [UpdateTracker:9791653] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v28:[updateIndirectRLE] [UpdateTracker:9788331] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789875] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v37:[updateIndirectRLE] [UpdateTracker:9788527] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v41:[updateIndirectRLE]

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