Reactome | CES3 hydrolyses CHEST to CHOL and LCFA(-)

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CES3 hydrolyses CHEST to CHOL and LCFA(-) Show undefined attributes

authored	[InstanceEdit:8937436] Jassal, Bijay, 2016-09-01
catalystActivity	[CatalystActivity:8937438] carboxylic ester hydrolase activity of CES3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13977] lipid droplet [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:8937436] Jassal, Bijay, 2016-09-01
dbId	8937442
displayName	CES3 hydrolyses CHEST to CHOL and LCFA(-)
edited	[InstanceEdit:8937436] Jassal, Bijay, 2016-09-01
eventOf	[Pathway:R-HSA-8964038] LDL clearance - Homo sapiens [Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens
followingEvent	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-163579] CHEST [lipid droplet] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8942489] Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing [LiteratureReference:8942491] Mammalian carboxylesterase 3: comparative genomics and proteomics
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	CES3 hydrolyses CHEST to CHOL and LCFA(-)
orthologousEvent	[Reaction:R-DDI-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Dictyostelium discoideum [Reaction:R-CEL-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Caenorhabditis elegans [Reaction:R-DME-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Drosophila melanogaster [Reaction:R-DRE-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Danio rerio [Reaction:R-SSC-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Sus scrofa [Reaction:R-BTA-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Bos taurus [Reaction:R-MMU-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Mus musculus
output	[SimpleEntity:R-ALL-216762] CHOL [transport vesicle membrane] [SimpleEntity:R-ALL-8876730] LCFA(-) [cytosol]
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942502] D'Eustachio, Peter, 2016-10-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8937442
summation	[Summation:8942496] In macrophage foam cells, the hydrolysis of cholesteryl este...

Referrals

(hasEvent)	[Pathway:R-HSA-211945] Phase I - Functionalization of compounds [Pathway:R-HSA-8964038] LDL clearance
(precedingEvent)	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane