Reactome | CYP3A4 binds CYP3A4 inhibitors

Schema > Reaction > Entries

CYP3A4 binds CYP3A4 inhibitors Show undefined attributes

authored	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
dbId	9678766
definition	Inhibition
displayName	CYP3A4 binds CYP3A4 inhibitors
edited	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-52639] CYP3A4 [endoplasmic reticulum membrane] [DefinedSet:R-ALL-9679016] CYP3A4 inhibitors [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9678732] Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions [LiteratureReference:9678622] Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies [LiteratureReference:9678942] Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes [LiteratureReference:9681265] Cobicistat, a pharmacoenhancer for HIV treatments [LiteratureReference:9681246] Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP3A4 binds CYP3A4 inhibitors
orthologousEvent	[Reaction:R-GGA-9678766] CYP3A4 binds CYP3A4 inhibitors - Gallus gallus [Reaction:R-XTR-9678766] CYP3A4 binds CYP3A4 inhibitors - Xenopus tropicalis [Reaction:R-DRE-9678766] CYP3A4 binds CYP3A4 inhibitors - Danio rerio [Reaction:R-SSC-9678766] CYP3A4 binds CYP3A4 inhibitors - Sus scrofa [Reaction:R-BTA-9678766] CYP3A4 binds CYP3A4 inhibitors - Bos taurus [Reaction:R-CFA-9678766] CYP3A4 binds CYP3A4 inhibitors - Canis familiaris [Reaction:R-RNO-9678766] CYP3A4 binds CYP3A4 inhibitors - Rattus norvegicus [Reaction:R-MMU-9678766] CYP3A4 binds CYP3A4 inhibitors - Mus musculus
output	[Complex:R-HSA-9679000] CYP3A4:CYP3A4 inhibitors [endoplasmic reticulum membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9678766
summation	[Summation:9681849] These compounds are inhibitors of cytochrome P450 3A enzymes...

Referrals

(hasEvent)

[Pathway:R-HSA-211945] Phase I - Functionalization of compounds