Reactome | ALD3A1 oxidises 4HPCP to CXPA

Schema > Reaction > Entries

ALD3A1 oxidises 4HPCP to CXPA Show undefined attributes

authored	[InstanceEdit:5692240] Jassal, Bijay, 2015-05-11
catalystActivity	[CatalystActivity:5692290] aldehyde dehydrogenase [NAD(P)+] activity of ALDH3A1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5692285] Jassal, Bijay, 2015-05-11
dbId	5692283
displayName	ALD3A1 oxidises 4HPCP to CXPA
edited	[InstanceEdit:5692240] Jassal, Bijay, 2015-05-11
eventOf	[Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens
input	[SimpleEntity:R-ALL-5692409] 4HPCP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5692289] RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide [LiteratureReference:5692284] Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ALD3A1 oxidises 4HPCP to CXPA
orthologousEvent	[Reaction:R-SCE-5692283] ALD3A1 oxidises 4HPCP to CXPA - Saccharomyces cerevisiae [Reaction:R-DDI-5692283] ALD3A1 oxidises 4HPCP to CXPA - Dictyostelium discoideum [Reaction:R-CEL-5692283] ALD3A1 oxidises 4HPCP to CXPA - Caenorhabditis elegans [Reaction:R-DME-5692283] ALD3A1 oxidises 4HPCP to CXPA - Drosophila melanogaster [Reaction:R-GGA-5692283] ALD3A1 oxidises 4HPCP to CXPA - Gallus gallus [Reaction:R-XTR-5692283] ALD3A1 oxidises 4HPCP to CXPA - Xenopus tropicalis [Reaction:R-DRE-5692283] ALD3A1 oxidises 4HPCP to CXPA - Danio rerio [Reaction:R-SSC-5692283] ALD3A1 oxidises 4HPCP to CXPA - Sus scrofa [Reaction:R-BTA-5692283] ALD3A1 oxidises 4HPCP to CXPA - Bos taurus [Reaction:R-RNO-5692283] ALD3A1 oxidises 4HPCP to CXPA - Rattus norvegicus [Reaction:R-MMU-5692283] ALD3A1 oxidises 4HPCP to CXPA - Mus musculus
output	[SimpleEntity:R-ALL-5692433] CXPA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-8941461] Positive regulation by 'AHR:TCDD:ARNT [nucleoplasm]' [NegativeRegulation:9625152] Negative regulation by 'AHRR:ARNT [nucleoplasm]'
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5692283
summation	[Summation:5692282] Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role...
updateTrackers	[UpdateTracker:9778719] Update Tracker - [Reaction:5692283] ALD3A1 oxidises 4HPCP to CXPA - v67:[addRegulator] [UpdateTracker:9782218] Update Tracker - [Reaction:5692283] ALD3A1 oxidises 4HPCP to CXPA - v59:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9778719] Update Tracker - [Reaction:5692283] ALD3A1 oxidises 4HPCP to CXPA - v67:[addRegulator] [UpdateTracker:9782218] Update Tracker - [Reaction:5692283] ALD3A1 oxidises 4HPCP to CXPA - v59:[addRegulator]
(hasEvent)	[Pathway:R-HSA-211945] Phase I - Functionalization of compounds

Cite Us!