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Schema
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Pathway
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Entries
FMO oxidises nucleophiles
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authored
[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
compartment
[Compartment:17957] endoplasmic reticulum lumen
created
[InstanceEdit:217275] Jassal, B, 2008-03-26 09:20:04
dbId
217271
displayName
FMO oxidises nucleophiles
edited
[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf
[Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens
figure
[Figure:114718] /figures/FMO_cat_cycle.JPG
goBiologicalProcess
[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-217255] FMO1:FAD N-oxidises TAM - Homo sapiens
[Reaction:R-HSA-217258] FMO2:FAD:Mg2+ S-oxidises MTZ - Homo sapiens
[Reaction:R-HSA-139970] FMO3:FAD N-oxidises TMA to TMAO - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023-09-13
literatureReference
[LiteratureReference:217277] The role of flavin-containing monooxygenases in drug metabolism and development
[LiteratureReference:217262] Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
maxDepth
2
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
FMO oxidises nucleophiles
orthologousEvent
[Pathway:R-CEL-217271] FMO oxidises nucleophiles - Caenorhabditis elegans
[Pathway:R-GGA-217271] FMO oxidises nucleophiles - Gallus gallus
[Pathway:R-XTR-217271] FMO oxidises nucleophiles - Xenopus tropicalis
[Pathway:R-DRE-217271] FMO oxidises nucleophiles - Danio rerio
[Pathway:R-SSC-217271] FMO oxidises nucleophiles - Sus scrofa
[Pathway:R-BTA-217271] FMO oxidises nucleophiles - Bos taurus
[Pathway:R-CFA-217271] FMO oxidises nucleophiles - Canis familiaris
[Pathway:R-RNO-217271] FMO oxidises nucleophiles - Rattus norvegicus
[Pathway:R-MMU-217271] FMO oxidises nucleophiles - Mus musculus
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised
[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-217271
summation
[Summation:114719] Flavin-containing monooxygenases (FMOs) are the second famil...
updateTrackers
[UpdateTracker:9786135] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v50:[modifyText, updateContainedRLE]
[UpdateTracker:9783984] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v55:[updateContainedRLE]
[UpdateTracker:9789581] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v37:[updateContainedRLE]
[UpdateTracker:9791597] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v28:[updateContainedRLE]
[UpdateTracker:9842325] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v86:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9786135] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v50:[modifyText, updateContainedRLE]
[UpdateTracker:9783984] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v55:[updateContainedRLE]
[UpdateTracker:9789581] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v37:[updateContainedRLE]
[UpdateTracker:9791597] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v28:[updateContainedRLE]
[UpdateTracker:9842325] Update Tracker - [Pathway:217271] FMO oxidises nucleophiles - v86:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-211945] Phase I - Functionalization of compounds
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