Reactome | FOXO3 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

FOXO3 [nucleoplasm] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9625445] FOXO1,(FOXO3) [nucleoplasm] - Homo sapiens
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9620884] FOXO3:BTG1 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-8952225] RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Homo sapiens [Reaction:R-HSA-9620891] FOXO3 binds BTG1 gene promoter - Homo sapiens [Reaction:R-NUL-9620900] FOXO3 binds Btg1 gene promoter - Homo sapiens [Reaction:R-NUL-9624615] FOXO3 binds Fbxo32 gene promoter - Homo sapiens [Reaction:R-HSA-9617972] FOXO3 binds SOD2 gene promoter - Homo sapiens [Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Homo sapiens [Reaction:R-HSA-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Homo sapiens [Reaction:R-HSA-8952226] RUNX3 binds the BCL2L11 (BIM) gene - Homo sapiens [Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Homo sapiens
created	[InstanceEdit:199263] Jassal, B, 2007-07-10 07:58:55
dbId	199305
displayName	FOXO3 [nucleoplasm]
endCoordinate	673
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-199305] Foxo3 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-199305] Foxo3 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-199305] FOXO3 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-199305] FOXO3 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-199305] FOXO3 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-199305] foxo3b [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-199305] foxo3 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-DME-199305] foxo [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-199305] daf-16 [nucleoplasm] - Caenorhabditis elegans
maxDepth	1
memberOf	[CandidateSet:R-HSA-9618003] FOXO3,(FOXO1,FOXO4) [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9617987] FOXO1,FOXO3,FOXO4 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9623398] FOXO1:PPARGC1A,FOXO3,FOXO4 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9623256] FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-6790042] STAT3-upregulated nuclear proteins [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9938525] D'Eustachio, Peter, 2025-02-17
name	FOXO3 Forkhead box protein O3A FOXO3_HUMAN FOXO3A
positivelyRegulates	[PositiveGeneExpressionRegulation:9699576] Positive gene expression regulation by 'FOXO3 [nucleoplasm]' [PositiveGeneExpressionRegulation:9699577] Positive gene expression regulation by 'FOXO3 [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Homo sapiens [BlackBoxEvent:R-HSA-9841812] FOXO3 translocates from the mitochondrial matrix to the nucleus - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:O43524] UniProt:O43524 FOXO3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-199305
startCoordinate	1
updateTrackers	[UpdateTracker:9939865] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v92:[modifyStartCoordinate] [UpdateTracker:9887843] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v46:[modifyStartCoordinate, removeName] [UpdateTracker:9872987] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v42:[addName] [UpdateTracker:9886896] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v45:[addName]

Referrals

(hasComponent)	[Complex:R-HSA-8952225] RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 gene [nucleoplasm] [Complex:R-HSA-9620884] FOXO3:BTG1 gene [nucleoplasm] [Complex:R-NUL-9620888] FOXO3:Btg1 gene [nucleoplasm] [Complex:R-NUL-9624650] FOXO3:Fbxo32 gene [nucleoplasm] [Complex:R-HSA-9617974] FOXO3:SOD2 gene [nucleoplasm] [Complex:R-HSA-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]
(input)	[Reaction:R-HSA-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR [Reaction:R-HSA-8952226] RUNX3 binds the BCL2L11 (BIM) gene [Reaction:R-HSA-9620891] FOXO3 binds BTG1 gene promoter [Reaction:R-NUL-9620900] FOXO3 binds Btg1 gene promoter [Reaction:R-NUL-9624615] FOXO3 binds Fbxo32 gene promoter [Reaction:R-HSA-9617972] FOXO3 binds SOD2 gene promoter [Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress [Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Reaction:R-HSA-9699579] AKT phosphorylates FOXO3 downstream of FLT3
(output)	[Reaction:R-HSA-9620532] SIRT1,SIRT3 deacetylate FOXO3 [BlackBoxEvent:R-HSA-9841812] FOXO3 translocates from the mitochondrial matrix to the nucleus
(hasMember)	[DefinedSet:R-HSA-6790042] STAT3-upregulated nuclear proteins [nucleoplasm] [DefinedSet:R-HSA-9617987] FOXO1,FOXO3,FOXO4 [nucleoplasm] [CandidateSet:R-HSA-9618003] FOXO3,(FOXO1,FOXO4) [nucleoplasm] [CandidateSet:R-HSA-199272] FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm] [CandidateSet:R-HSA-9620827] FOXO1,FOXO3,(FOXO4) [nucleoplasm] [DefinedSet:R-HSA-9614686] FOXO1,FOXO3 [nucleoplasm] [DefinedSet:R-HSA-9623421] FOXO3,FOXO4 [nucleoplasm] [CandidateSet:R-HSA-9617860] FOXO3,FOXO4,(FOXO1) [nucleoplasm] [CandidateSet:R-HSA-9622696] FOXO3,(FOXO1) [nucleoplasm] [CandidateSet:R-HSA-9622805] FOXO3,FOXO6,(FOXO1) [nucleoplasm] [DefinedSet:R-HSA-9623256] FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 [nucleoplasm] [DefinedSet:R-HSA-9623398] FOXO1:PPARGC1A,FOXO3,FOXO4 [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-8952231] Positive gene expression regulation by 'RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9620924] Positive gene expression regulation by 'FOXO3:BTG1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9617976] Positive gene expression regulation by 'FOXO3:SOD2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9699576] Positive gene expression regulation by 'FOXO3 [nucleoplasm]' [PositiveGeneExpressionRegulation:9699577] Positive gene expression regulation by 'FOXO3 [nucleoplasm]'
(hasCandidate)	[CandidateSet:R-HSA-9625445] FOXO1,(FOXO3) [nucleoplasm]
(regulator)	[PositiveGeneExpressionRegulation:9699576] Positive gene expression regulation by 'FOXO3 [nucleoplasm]' [PositiveGeneExpressionRegulation:9699577] Positive gene expression regulation by 'FOXO3 [nucleoplasm]'
(updatedInstance)	[UpdateTracker:9939865] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v92:[modifyStartCoordinate] [UpdateTracker:9887843] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v46:[modifyStartCoordinate, removeName] [UpdateTracker:9872987] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v42:[addName] [UpdateTracker:9886896] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v45:[addName]

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