Reactome | SIRT1,SIRT3 deacetylate FOXO3

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SIRT1,SIRT3 deacetylate FOXO3 Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
catalystActivity	[CatalystActivity:9622904] NAD-dependent protein lysine deacetylase activity of SIRT1,SIRT3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9620531] Orlic-Milacic, Marija, 2018-09-25
dbId	9620532
displayName	SIRT1,SIRT3 deacetylate FOXO3
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9620514] Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] 5 × [SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9620508] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [LiteratureReference:9622894] SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SIRT1,SIRT3 deacetylate FOXO3
orthologousEvent	[Reaction:R-CEL-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Caenorhabditis elegans [Reaction:R-DME-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Drosophila melanogaster [Reaction:R-DRE-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Danio rerio [Reaction:R-SSC-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Sus scrofa [Reaction:R-BTA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Bos taurus [Reaction:R-CFA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Canis familiaris [Reaction:R-RNO-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Rattus norvegicus [Reaction:R-MMU-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Mus musculus
output	5 × [SimpleEntity:R-ALL-427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199305] FOXO3 [nucleoplasm] 5 × [SimpleEntity:R-ALL-427497] NAM [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9620532
summation	[Summation:9620533] SIRT1, an NAD-dependent histone deacetylase, deacetylates FO...

Referrals

(hasEvent)

[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation