Reactome | KAT2B,EP300 acetylate FOXO3 under oxidative stress

Schema > Reaction > Entries

KAT2B,EP300 acetylate FOXO3 under oxidative stress Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
catalystActivity	[CatalystActivity:9620513] protein-lysine-acetyltransferase activity of KAT2B,(EP300) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9620511] Orlic-Milacic, Marija, 2018-09-25
dbId	9620515
displayName	KAT2B,EP300 acetylate FOXO3 under oxidative stress
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation - Homo sapiens
followingEvent	[Reaction:R-HSA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199305] FOXO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9620508] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KAT2B,EP300 acetylate FOXO3 under oxidative stress
orthologousEvent	[Reaction:R-CEL-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Caenorhabditis elegans [Reaction:R-DME-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Drosophila melanogaster [Reaction:R-XTR-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Xenopus tropicalis [Reaction:R-DRE-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Danio rerio [Reaction:R-SSC-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Sus scrofa [Reaction:R-BTA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Bos taurus [Reaction:R-CFA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Canis familiaris [Reaction:R-RNO-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Rattus norvegicus [Reaction:R-MMU-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9620514] Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] 5 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm]
regulatedBy	[PositiveRegulation:9620522] Positive regulation by 'ROS [nucleoplasm]'
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9620515
summation	[Summation:9620520] KAT2B (PCAF) and possibly EP300 (p300) acetylate FOXO3 under...

Referrals

(precedingEvent)	[Reaction:R-HSA-9620532] SIRT1,SIRT3 deacetylate FOXO3
(hasEvent)	[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation