Reactome | FOXO3 binds SOD2 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9617967] Orlic-Milacic, Marija, 2018-08-31
dbId	9617972
displayName	FOXO3 binds SOD2 gene promoter
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9617833] SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-199305] FOXO3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8870704] SOD2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9617975] Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FOXO3 binds SOD2 gene promoter
output	[Complex:R-HSA-9617974] FOXO3:SOD2 gene [nucleoplasm]
regulatedBy	[PositiveRegulation:9622881] Positive regulation by 'SIRT3 [nucleoplasm]'
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9617972
summation	[Summation:9617966] FOXO3 binds forkhead box elements in the promoter region of ...

(precedingEvent)	[BlackBoxEvent:R-HSA-9617833] SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
(hasEvent)	[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

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