Reactome | AKT phosphorylates FOXO3 downstream of FLT3

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AKT phosphorylates FOXO3 downstream of FLT3 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9699582] Rothfels, Karen, 2020-09-14
dbId	9699579
displayName	AKT phosphorylates FOXO3 downstream of FLT3
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199305] FOXO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699298] FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins [LiteratureReference:9696003] Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor [LiteratureReference:9624501] A brief introduction to FOXOlogy [LiteratureReference:9699307] FoxO transcription factors in cancer metabolism
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	AKT phosphorylates FOXO3 downstream of FLT3
orthologousEvent	[Reaction:R-CEL-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Caenorhabditis elegans [Reaction:R-DME-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Drosophila melanogaster [Reaction:R-DRE-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Danio rerio [Reaction:R-RNO-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Rattus norvegicus [Reaction:R-MMU-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Mus musculus
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm]
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9699579
summation	[Summation:9699397] AKT phosphorylation of the pro-apoptotic Forkhead transcript...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9699581] AKT-phosphorylated FOXO3 translocates to cytosol