Reactome | Vitamin D (calciferol) metabolism

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Vitamin D (calciferol) metabolism Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
dbId	196791
diseasePathways	[Pathway:R-HSA-5579027] Defective CYP27B1 causes VDDR1B - Homo sapiens [Pathway:R-HSA-5579014] Defective CYP27B1 causes VDDR1A - Homo sapiens
displayName	Vitamin D (calciferol) metabolism
doi	10.3180/R-HSA-196791.4
edited	[InstanceEdit:352314] Jassal, B, 2008-06-02 10:50:11
eventOf	[Pathway:R-HSA-8957322] Metabolism of steroids - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:11287] vitamin D metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-209754] Photolytic cleavage and thermal isomerization of 7-dehydroCHOL - Homo sapiens [BlackBoxEvent:R-HSA-8963872] VD3 translocates from ER membrane to extracellular region - Homo sapiens [Reaction:R-HSA-209738] VD3 binds GC - Homo sapiens [Reaction:R-HSA-8963851] VD3 dissociates from GC - Homo sapiens [BlackBoxEvent:R-HSA-350147] VD3 translocates from extracellular region to ER membrane - Homo sapiens [Reaction:R-HSA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Homo sapiens [BlackBoxEvent:R-HSA-6807242] 25(OH)D translocates from ER membrane to extracellular region - Homo sapiens [Reaction:R-HSA-209944] 25(OH)D binds GC - Homo sapiens [Reaction:R-HSA-350186] CUBN binds GC:25(OH)D - Homo sapiens [Reaction:R-HSA-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - Homo sapiens [BlackBoxEvent:R-HSA-209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen - Homo sapiens [BlackBoxEvent:R-HSA-350158] LGMN hydrolyzes GC, releasing CUBN and 25(OH)D - Homo sapiens [BlackBoxEvent:R-HSA-209766] 25(OH)D translocates from lysosomal lumen to cytosol - Homo sapiens [Reaction:R-HSA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Homo sapiens [Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Homo sapiens [BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm - Homo sapiens [Reaction:R-HSA-8963915] 1,25(OH)2D binds VDR - Homo sapiens [Reaction:R-HSA-4546387] PIAS4 SUMOylates VDR with SUMO2 - Homo sapiens [Reaction:R-HSA-9660192] VDR agonists bind VDR - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:8963930] Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Vitamin D (calciferol) metabolism
orthologousEvent	[Pathway:R-MMU-196791] Vitamin D (calciferol) metabolism - Mus musculus [Pathway:R-RNO-196791] Vitamin D (calciferol) metabolism - Rattus norvegicus [Pathway:R-CFA-196791] Vitamin D (calciferol) metabolism - Canis familiaris [Pathway:R-SSC-196791] Vitamin D (calciferol) metabolism - Sus scrofa [Pathway:R-DRE-196791] Vitamin D (calciferol) metabolism - Danio rerio [Pathway:R-XTR-196791] Vitamin D (calciferol) metabolism - Xenopus tropicalis [Pathway:R-GGA-196791] Vitamin D (calciferol) metabolism - Gallus gallus [Pathway:R-DME-196791] Vitamin D (calciferol) metabolism - Drosophila melanogaster [Pathway:R-CEL-196791] Vitamin D (calciferol) metabolism - Caenorhabditis elegans [Pathway:R-DDI-196791] Vitamin D (calciferol) metabolism - Dictyostelium discoideum [Pathway:R-BTA-196791] Vitamin D (calciferol) metabolism - Bos taurus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-196791
summation	[Summation:209942] Vitamin D3 (VD3, cholecalciferol) is a steroid hormone that ...
updateTrackers	[UpdateTracker:9775245] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v80:[updateContainedRLE] [UpdateTracker:9783998] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v55:[addHasEvent, updateContainedRLE] [UpdateTracker:9780736] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v62:[addHasEvent, updateContainedRLE] [UpdateTracker:9781767] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v60:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9774827] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v81:[addHasEvent] [UpdateTracker:9780260] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v63:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9790620] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v33:[updateContainedRLE] [UpdateTracker:9786970] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v46:[updateContainedRLE] [UpdateTracker:9776884] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v74:[updateContainedRLE] [UpdateTracker:9964618] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v94:[addHasEvent] [UpdateTracker:9786144] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v50:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-8957322] Metabolism of steroids
(hasEncapsulatedEvent)	[Pathway:R-HSA-5652084] Fructose metabolism [Pathway:R-HSA-191273] Cholesterol biosynthesis
(normalPathway)	[Pathway:R-HSA-5579027] Defective CYP27B1 causes VDDR1B [Pathway:R-HSA-5579014] Defective CYP27B1 causes VDDR1A
(updatedInstance)	[UpdateTracker:9775245] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v80:[updateContainedRLE] [UpdateTracker:9783998] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v55:[addHasEvent, updateContainedRLE] [UpdateTracker:9780736] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v62:[addHasEvent, updateContainedRLE] [UpdateTracker:9781767] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v60:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9774827] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v81:[addHasEvent] [UpdateTracker:9780260] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v63:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9790620] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v33:[updateContainedRLE] [UpdateTracker:9786970] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v46:[updateContainedRLE] [UpdateTracker:9776884] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v74:[updateContainedRLE] [UpdateTracker:9964618] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v94:[addHasEvent] [UpdateTracker:9786144] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v50:[updateContainedRLE]

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