Reactome | PIAS4 SUMOylates VDR with SUMO2

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PIAS4 SUMOylates VDR with SUMO2 Show undefined attributes

authored	[InstanceEdit:4341133] May, B, 2013-08-18
catalystActivity	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643693] SUMO transferase activity of PIAS4 [nucleoplasm] PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4546388] May, B, 2013-09-05
dbId	4546387
displayName	PIAS4 SUMOylates VDR with SUMO2
edited	[InstanceEdit:4341133] May, B, 2013-08-18
eventOf	[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism - Homo sapiens [Pathway:R-HSA-4090294] SUMOylation of intracellular receptors - Homo sapiens
input	2 × [Complex:R-HSA-2993778] SUMO2:UBE2I [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-375512] VDR [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4546366] PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PIAS4 SUMOylates VDR with SUMO2
orthologousEvent	[Reaction:R-BTA-4546387] PIAS4 SUMOylates VDR with SUMO2 - Bos taurus [Reaction:R-DME-4546387] PIAS4 SUMOylates VDR with SUMO2 - Drosophila melanogaster [Reaction:R-GGA-4546387] PIAS4 SUMOylates VDR with SUMO2 - Gallus gallus [Reaction:R-XTR-4546387] PIAS4 SUMOylates VDR with SUMO2 - Xenopus tropicalis [Reaction:R-DRE-4546387] PIAS4 SUMOylates VDR with SUMO2 - Danio rerio [Reaction:R-SSC-4546387] PIAS4 SUMOylates VDR with SUMO2 - Sus scrofa [Reaction:R-RNO-4546387] PIAS4 SUMOylates VDR with SUMO2 - Rattus norvegicus [Reaction:R-MMU-4546387] PIAS4 SUMOylates VDR with SUMO2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4546376] polySUMO2-VDR [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4546387
summation	[Summation:4546342] E3 SUMO-protein ligase (PIAS4) SUMOylates Vitamin D3 recepto...

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