Reactome | CUBN binds GC:25(OH)D

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CUBN binds GC:25(OH)D Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:9959975] cargo receptor activity of CUBN [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:350121] Jassal, Bijay, 2008-05-14
dbId	350186
displayName	CUBN binds GC:25(OH)D
edited	[InstanceEdit:352314] Jassal, B, 2008-06-02 10:50:11
eventOf	[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-264843] CUBN [plasma membrane] [Complex:R-HSA-209892] GC:25(OH)D [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:350165] Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	CUBN binds GC:25(OH)D DBP:Calcidiol is sequestered by cubilin on the cell surface
orthologousEvent	[Reaction:R-BTA-350186] CUBN binds GC:25(OH)D - Bos taurus [Reaction:R-RNO-350186] CUBN binds GC:25(OH)D - Rattus norvegicus
output	[Complex:R-HSA-350115] CUBN:GC:25(OH)D [plasma membrane]
precedingEvent	[Reaction:R-HSA-209944] 25(OH)D binds GC - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9963238] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-350186
summation	[Summation:350100] Cubilin (CUBN) is a membrane-associated protein colocalising...
updateTrackers	[UpdateTracker:9781729] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v60:[modifyText] [UpdateTracker:9964610] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v94:[removeCatalystActivity] [UpdateTracker:9787109] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v46:[modifyText] [UpdateTracker:9780471] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v63:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781729] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v60:[modifyText] [UpdateTracker:9964610] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v94:[removeCatalystActivity] [UpdateTracker:9787109] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v46:[modifyText] [UpdateTracker:9780471] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v63:[modifyText]
(hasEvent)	[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism
(precedingEvent)	[Reaction:R-HSA-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D