Reactome | CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

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CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:209953] calcidiol 1-monooxygenase activity of CYP27B1(?-508) [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
dbId	209868
diseaseReaction	[FailedReaction:R-HSA-5602186] Defective CYP27B1 does not hydroxylate CDL - Homo sapiens
displayName	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211916] Vitamins - Homo sapiens [Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Homo sapiens [BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm - Homo sapiens
input	[SimpleEntity:R-ALL-209804] 25(OH)D [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:215612] Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion [LiteratureReference:215593] Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells [LiteratureReference:8963849] Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
orthologousEvent	[Reaction:R-DRE-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Danio rerio [Reaction:R-SSC-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Sus scrofa [Reaction:R-BTA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Bos taurus [Reaction:R-CFA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Canis familiaris [Reaction:R-RNO-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Rattus norvegicus [Reaction:R-MMU-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Mus musculus
output	[SimpleEntity:R-ALL-209800] 1,25(OH)2D [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-209766] 25(OH)D translocates from lysosomal lumen to cytosol - Homo sapiens [Reaction:R-HSA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Homo sapiens
regulatedBy	[NegativeRegulation:9692889] Negative regulation by 'Fru [cytosol]'
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-209868
summation	[Summation:215621] The second step in vitamin D activation requires hydroxylati...
updateTrackers	[UpdateTracker:9776772] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v74:[addRegulator] [UpdateTracker:9786174] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v50:[modifyText] [UpdateTracker:9782011] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v60:[addLiteratureReference, modifyText] [UpdateTracker:9780398] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v63:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776772] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v74:[addRegulator] [UpdateTracker:9786174] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v50:[modifyText] [UpdateTracker:9782011] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v60:[addLiteratureReference, modifyText] [UpdateTracker:9780398] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v63:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5602186] Defective CYP27B1 does not hydroxylate CDL
(hasEvent)	[Pathway:R-HSA-211916] Vitamins [Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism
(precedingEvent)	[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it [BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm

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