Reactome | Vitamin D (calciferol) metabolism

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Vitamin D (calciferol) metabolism Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444198
displayName	Vitamin D (calciferol) metabolism
eventOf	[Pathway:R-BTA-8957322] Metabolism of steroids - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:11287] vitamin D metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-209738] VD3 binds GC - Bos taurus [Reaction:R-BTA-8963851] VD3 dissociates from GC - Bos taurus [Reaction:R-BTA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Bos taurus [Reaction:R-BTA-209944] 25(OH)D binds GC - Bos taurus [Reaction:R-BTA-350186] CUBN binds GC:25(OH)D - Bos taurus [Reaction:R-BTA-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - Bos taurus [BlackBoxEvent:R-BTA-209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen - Bos taurus [BlackBoxEvent:R-BTA-350158] LGMN hydrolyzes GC, releasing CUBN and 25(OH)D - Bos taurus [Reaction:R-BTA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Bos taurus [Reaction:R-BTA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Bos taurus [Reaction:R-BTA-8963915] 1,25(OH)2D binds VDR - Bos taurus [Reaction:R-BTA-4546387] PIAS4 SUMOylates VDR with SUMO2 - Bos taurus [Reaction:R-BTA-9660192] VDR agonists bind VDR - Bos taurus
inferredFrom	[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Vitamin D (calciferol) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-196791
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8957322] Metabolism of steroids
(hasEncapsulatedEvent)	[Pathway:R-BTA-5652084] Fructose metabolism [Pathway:R-BTA-191273] Cholesterol biosynthesis
(inferredTo)	[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism

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