Reactome | Mature NOTCH heterodimer traffics to the plasma membrane

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Mature NOTCH heterodimer traffics to the plasma membrane Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1912383] Orlic-Milacic, M, 2011-11-01
dbId	1912382
deleted	[Deleted:5694741] Deletion of instance: 157117 [Deleted:5694727] Deletion of instance: 157151 [Deleted:5694732] Deletion of instance: 157076 [Deleted:5694733] Deletion of instance: 157000 [Deleted:6792898] Deletion of instance: 157128
displayName	Mature NOTCH heterodimer traffics to the plasma membrane
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
followingEvent	[Reaction:R-HSA-2974737] NOTCH2 binds MDK - Homo sapiens [Reaction:R-HSA-9911648] NOTCH2 binds DLL/JAG ligand in cis - Homo sapiens [Reaction:R-HSA-1980048] DLL1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980051] DLL4 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-2220816] NOTCH2 binds CNTN1 - Homo sapiens [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980061] JAG2 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH - Homo sapiens [Reaction:R-HSA-1980130] NOTCH1 binds DLK1 - Homo sapiens [Reaction:R-HSA-1980138] NOTCH1 binds DLL/JAG ligand in cis - Homo sapiens [Reaction:R-HSA-1980122] DTX binds NOTCH1 - Homo sapiens [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 - Homo sapiens [Reaction:R-HSA-1980041] NOTCH1 binds DLL4 - Homo sapiens [Reaction:R-HSA-1980042] NOTCH1 binds JAG1 - Homo sapiens [Reaction:R-HSA-1980044] NOTCH1 binds JAG2 - Homo sapiens [Reaction:R-HSA-157145] NOTCH3 binds DLL1 - Homo sapiens
input	[DefinedSet:R-HSA-1911472] NOTCH [Golgi membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [LiteratureReference:157051] Oh no, Notch again! [LiteratureReference:1911393] p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Mature NOTCH heterodimer traffics to the plasma membrane
orthologousEvent	[BlackBoxEvent:R-DME-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Drosophila melanogaster [BlackBoxEvent:R-GGA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Gallus gallus [BlackBoxEvent:R-XTR-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Xenopus tropicalis [BlackBoxEvent:R-DRE-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Danio rerio [BlackBoxEvent:R-SSC-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Sus scrofa [BlackBoxEvent:R-BTA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Bos taurus [BlackBoxEvent:R-RNO-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Mus musculus
output	[DefinedSet:R-HSA-1911474] NOTCH [plasma membrane]
precedingEvent	[Reaction:R-HSA-1912369] NOTCH precursor cleaved to form mature NOTCH - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2043096] Negative regulation by 'TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]'
regulationReference	[RegulationReference:9641452] Negative regulation by 'TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]' p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912382
summation	[Summation:1912381] Mature NOTCH translocates from the Golgi to plasma membrane....

Referrals

(replacementInstances)	[Deleted:6792898] Deletion of instance: 157128 [Deleted:5694741] Deletion of instance: 157117 [Deleted:5694727] Deletion of instance: 157151 [Deleted:5694732] Deletion of instance: 157076 [Deleted:5694733] Deletion of instance: 157000
(precedingEvent)	[Reaction:R-HSA-2974737] NOTCH2 binds MDK [Reaction:R-HSA-9911648] NOTCH2 binds DLL/JAG ligand in cis [Reaction:R-HSA-1980048] DLL1 binds NOTCH2 [Reaction:R-HSA-1980051] DLL4 binds NOTCH2 [Reaction:R-HSA-2220816] NOTCH2 binds CNTN1 [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 [Reaction:R-HSA-1980061] JAG2 binds NOTCH2 [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH [Reaction:R-HSA-1980130] NOTCH1 binds DLK1 [Reaction:R-HSA-1980138] NOTCH1 binds DLL/JAG ligand in cis [Reaction:R-HSA-1980122] DTX binds NOTCH1 [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 [Reaction:R-HSA-1980041] NOTCH1 binds DLL4 [Reaction:R-HSA-1980042] NOTCH1 binds JAG1 [Reaction:R-HSA-1980044] NOTCH1 binds JAG2 [Reaction:R-HSA-157145] NOTCH3 binds DLL1
(hasEvent)	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi

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