Mature NOTCH heterodimer traffics to the plasma membrane

Stable Identifier
R-HSA-1912382
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

Literature References
PubMed ID Title Journal Year
11135303 Oh no, Notch again!

Frisen, J, Lendahl, U

Bioessays 2001
10366590 p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans

Wen, C, Greenwald, I

J Cell Biol 1999
9244302 Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

Blaumueller, CM, Qi, H, Zagouras, P, Artavanis-Tsakonas, S

Cell 1997
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Orthologous Events
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