Reactome | Mature NOTCH heterodimer traffics to the plasma membrane

Mature NOTCH heterodimer traffics to the plasma membrane

Stable Identifier

R-HSA-1912382

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Mature NOTCH heterodimer traffics to the plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

Literature References

PubMed ID	Title	Journal	Year
10366590	p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans Wen, C, Greenwald, I	J Cell Biol	1999
11135303	Oh no, Notch again! Frisen, J, Lendahl, U	Bioessays	2001
9244302	Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Blaumueller, CM, Qi, H, Zagouras, P, Artavanis-Tsakonas, S	Cell	1997